Drugs / FHA11KRASG12V-TCR
last change Dec 2023 re-read 3 minutes ago

FHA11KRASG12V-TCR

Cell therapy targets KRAS via depletion

Developed for
metastatic malignant neoplasm
Investigated by
Affini-T Therapeutics, Inc. · Fred Hutchinson Cancer Center · National Cancer Institute (NCI)

Trials 1

20242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT06043713 Dec 2023 → Jan 2028 expected metastatic malignant neoplasm Fred Hutchinson Cancer Center Recruiting No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 1 source stands behind the page.

FieldValueCited text
Known as FHA11KRASG12V-TCR “This phase I trial studies the side effects and best dose of autologous CD8+ and CD4+ transgenic T cells expressing high affinity KRASG12V mutation-specific T cell receptors...” NCT06043713 ↗
1

“Patients then receive FHA11KRASG12V-TCR IV on day 0.” NCT06043713 ↗

Action Deplete “can kill tumor cells.” NCT06043713 ↗
Modality Cell therapy “autologous CD8+ and CD4+ transgenic T cells” NCT06043713 ↗
Route Intravenous “Receive FHA11KRASG12V-TCR IV” NCT06043713 ↗
Target KRAS “recognize KRAS G12V” NCT06043713 ↗