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Drugs / Pinometostat
last change Nov 2022 re-read 2 minutes ago

Pinometostat

also known as EPZ-5676 · EPZ-005676 · Pinometostat anhydrous

Small molecule targets DOT1L via inhibition

Developed for
acute myeloid leukemia · acute lymphoblastic leukemia · acute myeloid leukemia, t(9;11)(p21.3;q23.3) · myelodysplastic syndrome
Investigated by
Celgene Corporation · Epizyme, Inc. · National Cancer Institute (NCI)

Trials 4 · a red edge is where a trial was stopped

today NCT03701295 · Ph 1/2 NCT03724084 · Ph 1/2 NCT02141828 · Ph 1 NCT01684150 · Ph 1
201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT02141828 May 2014 → May 2016 acute lymphoblastic leukemia, acute myeloid leukemia Epizyme, Inc. Completed No outcome recorded
Phase 1 NCT01684150 Sep 2012 → Nov 2015 acute lymphoblastic leukemia, acute myeloid leukemia, myelodysplastic syndrome Epizyme, Inc. Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT03701295 Mar → Dec 2020 acute myeloid leukemia, t(9;11)(p21.3;q23.3) National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/2 NCT03724084 Apr 2019 → Nov 2022 acute myeloid leukemia National Cancer Institute (NCI) Terminated No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as Pinometostat “Pinometostat (EPZ-5676) is a first-in-class small-molecule inhibitor of the histone methyltransferase disrupter of telomeric silencing 1-like (DOT1L).” PMID 29724899 ↗ May 2018
2

NCT03701295 ↗

NCT03724084 ↗
Known as EPZ-005676 ChEMBL registry synonym — accepted as the source's own label CHEMBL3414626 ↗
Known as EPZ-5676 “Pinometostat (EPZ-5676) is a first-in-class small-molecule inhibitor of the histone methyltransferase disrupter of telomeric silencing 1-like (DOT1L).” PMID 29724899 ↗ May 2018
1

NCT02141828 ↗
Known as Pinometostat anhydrous ChEMBL registry synonym — accepted as the source's own label CHEMBL3414626 ↗
Action Inhibit “blocks the activity of DOT1L” NCT01684150 ↗
Modality Small molecule “first-in-class small-molecule inhibitor” PMID 29724899 ↗ May 2018
Route Intravenous “by continuous intravenous infusion” PMID 29724899 ↗ May 2018
Target DOT1L “inhibitor of the histone methyltransferase disrupter of telomeric silencing 1-like (DOT1L)” PMID 29724899 ↗ May 2018