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Drugs / pefcalcitol
last change Dec 2019 re-read 2 minutes ago

pefcalcitol

also known as M518101 · M5181

Small molecule targets VDR via activation

Developed for
psoriasis
Investigated by
Maruho North America Inc. · Maruho Co., Ltd. · Maruho Europe Limited

Trials 9 · a red edge is where a trial was stopped

today NCT02970331 · Ph 2 NCT02256930 · Ph 1 NCT02227069 · Ph 1 NCT01989429 · Ph 3 NCT01908595 · Ph 3 NCT01873677 · Ph 3 NCT01878461 · Ph 3 NCT01301157 · Ph 2 NCT00884169 · Ph 2
201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT02256930 Sep → Nov 2014 — Maruho North America Inc. Completed No outcome recorded
Phase 1 NCT02227069 Sep → Oct 2014 — Maruho North America Inc. Completed No outcome recorded
Phase 23 trials
Phase 2 NCT02970331 Jun → Dec 2019 psoriasis Maruho Co., Ltd. Withdrawn No outcome recorded
Phase 2 NCT01301157 Feb 2011 → Jan 2012 psoriasis Maruho Co., Ltd. Completed No outcome recorded
Phase 2 NCT00884169 Jul → Dec 2009 psoriasis Maruho Co., Ltd. Completed No outcome recorded
Phase 34 trials
Phase 3 NCT01989429 Oct 2013 → Dec 2014 psoriasis Maruho Europe Limited Completed No outcome recorded
Phase 3 NCT01908595 Aug 2013 → May 2015 psoriasis Maruho North America Inc. Completed No outcome recorded
Phase 3 NCT01873677 Jun 2013 → Apr 2015 psoriasis Maruho North America Inc. Completed No outcome recorded
Phase 3 NCT01878461 Jun 2013 → May 2015 psoriasis Maruho North America Inc. Completed No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT01844973 Comparator Apr → Aug 2013 psoriasis Maruho North America Inc. Completed No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 11 sources stand behind the page.

FieldValueCited text
Known as pefcalcitol ClinicalTrials.gov intervention name — accepted as the source's own label NCT02970331 ↗
Known as M5181 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01989429 ↗
Known as M518101 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01301157 ↗
7

NCT01844973 ↗

NCT02256930 ↗

NCT01908595 ↗

NCT01878461 ↗

NCT01873677 ↗

NCT02227069 ↗

NCT00884169 ↗
Action Activate “Vitamin D receptor agonist” CHEMBL3989862 ↗
Modality Small molecule “M5181 - a novel vitamin D3 analogue” NCT01989429 ↗
1

CHEMBL3989862 ↗
Route Topical “topical application” NCT01989429 ↗
Target VDR “Vitamin D receptor agonist” CHEMBL3989862 ↗