Drugs / JNJ-42165279
last change Oct 2022 re-read 3 minutes ago

JNJ-42165279

Small molecule targets FAAH via inhibition

Developed for
anxiety · autism spectrum disorder · depressive disorder · phobic disorder
Investigated by
Janssen Research & Development, LLC · Janssen Pharmaceutica N.V., Belgium · Janssen-Cilag International NV

Trials 9

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 16 trials
Phase 1 NCT03564379 Jun → Aug 2018 — Janssen Research & Development, LLC Completed No outcome recorded
Phase 1 NCT02169973 Feb → Jul 2014 — Janssen Research & Development, LLC Completed No outcome recorded
Phase 1 NCT02065739 Jan → Mar 2014 — Janssen Pharmaceutica N.V., Belgium Completed No outcome recorded
Phase 1 NCT01964651 Oct 2013 → Oct 2014 — Janssen Research & Development, LLC Completed No outcome recorded
Phase 1 NCT01826786 Aug 2013 → Aug 2014 — Janssen Research & Development, LLC Completed No outcome recorded
Phase 1 NCT01650597 Aug 2011 → May 2012 — Janssen-Cilag International NV Completed No outcome recorded
Phase 23 trials · 3 missed
Phase 2 NCT03664232 Nov 2018 → Oct 2022 autism spectrum disorder Janssen Research & Development, LLC Completed Missed primary
Phase 2 NCT02498392 Oct 2015 → Feb 2019 anxiety, depressive disorder Janssen Research & Development, LLC Completed Missed primary
Phase 2 NCT02432703 Jun 2015 → Aug 2018 phobic disorder Janssen Research & Development, LLC Completed Missed primary

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 11 sources stand behind the page.

FieldValueCited text
Known as JNJ-42165279 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01826786 ↗
8

NCT02065739 ↗

NCT03664232 ↗

NCT03564379 ↗

NCT02432703 ↗

NCT01650597 ↗

NCT02498392 ↗

NCT01964651 ↗

NCT02169973 ↗

Action Inhibit “The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279” PMID 33070154 ↗ Oct 2020
Modality Small molecule — CHEMBL4297294 ↗
Route Oral “route=oral use. One single dose administered orally.” NCT01650597 ↗
Target FAAH “JNJ-42165279 is a selective inhibitor of fatty acid amide hydrolase (FAAH)” PMID 33070154 ↗ Oct 2020