Drugs / ethacrynic acid
ethacrynic acid
also known as
Acide etacrynique · Acido etacrinico · Edecrin · Etacrynic acid · Hydromedin · MK-595 · NSC-624008 · NSC-85791 · +1 more
Small molecule targets SLC12A1 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | EDECRIN | — | 1967-01-10 | fda.gov ↗ |
Trials 2 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT02852564 | Aug 2016 → Jul 2017 | urinary bladder cancer | Eugene Lee, MD | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT02051946 | May 2014 → Oct 2015 | glaucoma | Molly Walsh | Completed | No outcome recorded |
Also used as a comparator or background therapy in 1 trial
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 3 | NCT01628731 Comparator | Oct 2012 → Jul 2013 | — | Bambino Gesù Hospital and Research Institute | Completed | No outcome recorded |
Evidence & citations 14 cited values
Every value below carries the sentence it was read from. 4 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Ethacrynic Acid | ClinicalTrials.gov intervention name — accepted as the source's own label NCT02852564 ↗ |
| Known as | Acide etacrynique | ChEMBL registry synonym — accepted as the source's own label CHEMBL456 ↗ |
| Known as | Acido etacrinico | ChEMBL registry synonym — accepted as the source's own label CHEMBL456 ↗ |
| Known as | Edecrin | ChEMBL registry synonym — accepted as the source's own label CHEMBL456 ↗ |
| Known as | Etacrynic acid | ChEMBL registry synonym — accepted as the source's own label CHEMBL456 ↗ |
| Known as | Hydromedin | ChEMBL registry synonym — accepted as the source's own label CHEMBL456 ↗ |
| Known as | MK-595 | ChEMBL registry synonym — accepted as the source's own label CHEMBL456 ↗ |
| Known as | NSC-624008 | ChEMBL registry synonym — accepted as the source's own label CHEMBL456 ↗ |
| Known as | NSC-85791 | ChEMBL registry synonym — accepted as the source's own label CHEMBL456 ↗ |
| Known as | Reomax | ChEMBL registry synonym — accepted as the source's own label CHEMBL456 ↗ |
| Action | Inhibit | “Sodium-(potassium)-chloride cotransporter 2 inhibitor” CHEMBL456 ↗ |
| Modality | Small molecule | — CHEMBL456 ↗ |
| Route | Intravenous | “ethacrynic acid, intravenous, continuous infusion, 0.2 mg/kg/h for 24 hours” NCT01628731 ↗ |
| Target | SLC12A1 | “Sodium-(potassium)-chloride cotransporter 2 inhibitor” CHEMBL456 ↗ |