Drugs / methantheline
methantheline
also known as
Banthine · Bromure de methanthelinium · Bromuro de metantelinio · methantheline bromide · Methantheline cation · Methantheline ion · Methanthelinium · Methanthelinium bromide · +2 more
Small molecule targets HRH2 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | BANTHINE | — | 1951-07-03 | fda.gov ↗ |
Trials 1
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| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1 | NCT01429090 | Oct → Nov 1999 | — | University Medicine Greifswald | Completed | Missed primary |
Evidence & citations 15 cited values
Every value below carries the sentence it was read from. 2 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | methantheline | “The quarternary anticholinergic compound methantheline bromide (diethyl-methyl \[2-(9 xanthenyl carbonyloxy) ethyl\] ammonium bromide) is marketed to treat neurogenic bladder...” NCT01429090 ↗ |
| Known as | Banthine | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201264 ↗ |
| Known as | Bromure de methanthelinium | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201264 ↗ |
| Known as | Bromuro de metantelinio | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201264 ↗ |
| Known as | methantheline bromide | “The quarternary anticholinergic compound methantheline bromide (diethyl-methyl \[2-(9 xanthenyl carbonyloxy) ethyl\] ammonium bromide) is marketed to treat neurogenic bladder...” NCT01429090 ↗ |
| Known as | Methantheline cation | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201264 ↗ |
| Known as | Methantheline ion | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201264 ↗ |
| Known as | Methanthelinium | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201264 ↗ |
| Known as | Methanthelinium bromide | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201264 ↗ |
| Known as | NSC-32145 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201264 ↗ |
| Known as | Vagantin | “Vagantin® is marketed as coated tablets containing 50 mg methantheline bromide.” NCT01429090 ↗ |
| Action | Inhibit | “it influences the parasympathetic nervous transmission more by ganglionic rather than peripheral muscarinic receptor blockade.” NCT01429090 ↗1“Histamine H2 receptor antagonist” CHEMBL1201264 ↗ |
| Modality | Small molecule | — CHEMBL1201264 ↗ |
| Route | Oral | “single oral dose administration of Vagantin® coated tablets” NCT01429090 ↗ |
| Target | HRH2 | “Histamine H2 receptor antagonist” CHEMBL1201264 ↗ |