Drugs / Elismetrep
last change Jul 2026 re-read 2 minutes ago

Elismetrep

also known as MT 8554 · K-304

Small molecule targets TRPM8 via inhibition

Developed for
migraine disorder · diabetic polyneuropathy · premature menopause
Investigated by
Tanabe Pharma Corporation · Tanabe Pharma America, Inc. · Kallyope Inc.

Trials 13 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 16 trials
Phase 1 NCT03471130 Apr → Oct 2018 Tanabe Pharma America, Inc. Completed No outcome recorded
Phase 1 NCT03381404 Dec 2017 → Jan 2018 Tanabe Pharma America, Inc. Completed No outcome recorded
Phase 1 NCT02803268 Jun 2016 → Jan 2017 Tanabe Pharma Corporation Completed No outcome recorded
Phase 1 NCT02675309 Feb → Mar 2016 Tanabe Pharma Corporation Completed No outcome recorded
Phase 1 NCT02536209 Aug → Nov 2015 Tanabe Pharma Corporation Completed No outcome recorded
Phase 1 NCT02429102 Apr → Nov 2015 Tanabe Pharma Corporation Completed No outcome recorded
Phase 25 trials
Phase 2 NCT06848075 Mar → Aug 2025 migraine disorder Kallyope Inc. Completed No outcome recorded
Phase 2 NCT05123196 Nov 2021 → Nov 2022 diabetic polyneuropathy Tanabe Pharma Corporation Completed No outcome recorded
Phase 2 NCT03541200 Apr 2018 → Nov 2019 Tanabe Pharma America, Inc. Completed No outcome recorded
Phase 2 NCT03291067 Oct 2017 → Oct 2018 premature menopause Tanabe Pharma America, Inc. Completed No outcome recorded
Phase 2 NCT03172598 Jul 2017 → Aug 2018 diabetic polyneuropathy Tanabe Pharma Corporation Completed No outcome recorded
Phase 32 trials
Phase 3 NCT07674654 Jul 2026 → Jun 2028 expected migraine disorder Kallyope Inc. Not yet recruiting No outcome recorded
Phase 3 NCT07645924 Jul 2026 → Feb 2027 expected migraine disorder Kallyope Inc. Recruiting No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 14 sources stand behind the page.

FieldValueCited text
Known as Elismetrep ClinicalTrials.gov intervention name — accepted as the source's own label NCT07674654
2

NCT06848075

NCT07645924

Known as K-304 “Elismetrep (K-304) Dose Level 1” NCT06848075
1

“Elismetrep (K-304)” NCT07645924

Known as MT 8554 “This is a study to definitively assess the effects of MT 8554, adjusted for placebo, on the change of the QT interval corrected for heart rate (HR) using the Fridericia formula...” NCT03471130
10

NCT02675309

NCT02803268

NCT02429102

NCT03291067

NCT03381404

NCT03172598

NCT03471130

NCT02536209

NCT03541200

NCT05123196

Action Inhibit “Transient receptor potential cation channel subfamily M member 8 inhibitor” CHEMBL3682589
Modality Small molecule CHEMBL3682589
Route Oral “MT-8554 1mg QD, oral, 12 weeks” NCT03291067
Target TRPM8 “Transient receptor potential cation channel subfamily M member 8 inhibitor” CHEMBL3682589