Drugs / PF-06291874
last change Aug 2016 re-read 3 minutes ago

PF-06291874

Small molecule targets GCGR via inhibition

Developed for
type 2 diabetes mellitus
Investigated by
Pfizer

Trials 5

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT01856595 May 2013 → Jan 2014 type 2 diabetes mellitus Pfizer Completed Mixed
Phase 1 NCT01794364 Jan → Mar 2013 — Pfizer Completed No outcome recorded
Phase 1 NCT01499017 Nov 2011 → Jan 2012 — Pfizer Terminated No outcome recorded
Phase 22 trials · 1 met primary
Phase 2 NCT02554877 Oct 2015 → Aug 2016 type 2 diabetes mellitus Pfizer Completed Met primary
Phase 2 NCT02175121 Aug 2014 → Mar 2015 type 2 diabetes mellitus Pfizer Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as PF-06291874 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01856595 ↗
4

NCT02554877 ↗

NCT01499017 ↗

NCT01794364 ↗

NCT02175121 ↗

Action Inhibit “Glucagon receptor antagonist” CHEMBL2381848 ↗
Modality Small molecule — CHEMBL2381848 ↗
Route Oral “single oral doses of PF-06291874 in healthy volunteers.” NCT01499017 ↗
Target GCGR “Glucagon receptor antagonist” CHEMBL2381848 ↗