Drugs / Balovaptan
last change Oct 2023 re-read 2 minutes ago

Balovaptan

also known as RO5285119 · RG7314

Small molecule targets AVPR1A via inhibition

Developed for
autism spectrum disorder · ischemic stroke · post-traumatic stress disorder
Investigated by
Hoffmann-La Roche

Trials 17 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 112 trials
Phase 1 NCT03912350 Jun → Sep 2022 autism spectrum disorder Hoffmann-La Roche Withdrawn No outcome recorded
Phase 1 NCT04049578 Dec 2019 → Apr 2020 autism spectrum disorder Hoffmann-La Roche Terminated No outcome recorded
Phase 1 NCT04156646 Nov → Dec 2019 autism spectrum disorder Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT03808298 Feb → Jun 2019 Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT03764449 Jan → Mar 2019 Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT03586726 Jul → Nov 2018 Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT03579719 Jul → Nov 2018 Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT02205073 Jul 2014 → Oct 2015 Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT02179866 Jun → Jul 2014 Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT01967979 Oct → Dec 2013 Hoffmann-La Roche Completed No outcome recorded
Phase 24 trials
Phase 2 NCT05401565 Aug 2022 → Oct 2023 post-traumatic stress disorder Hoffmann-La Roche Completed No outcome recorded
Phase 2 NCT05399550 Jun → Nov 2022 ischemic stroke Hoffmann-La Roche Withdrawn No outcome recorded
Phase 2 NCT02901431 Nov 2016 → Apr 2020 autism spectrum disorder Hoffmann-La Roche Terminated No outcome recorded
Phase 2 NCT01793441 Sep 2013 → Sep 2016 autism spectrum disorder Hoffmann-La Roche Completed No outcome recorded
Phase 31 trial
Phase 3 NCT03504917 Aug 2018 → Mar 2020 autism spectrum disorder Hoffmann-La Roche Terminated No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 19 sources stand behind the page.

FieldValueCited text
Known as balovaptan “BACKGROUND: Balovaptan is a potent, selective vasopressin 1a receptor antagonist.” PMID 34176392 Jul 2021
11

Balovaptan (RO5285119) 10 mg/d equivalent” NCT02901431

NCT05399550

NCT03912350

NCT03504917

NCT03808298

NCT04049578

NCT05401565

NCT03586726

NCT03579719

NCT04156646

NCT03764449

Known as RG7314 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02205073
1

NCT01793441

Known as RO5285119 “Balovaptan (RO5285119) 10 mg/d equivalent” NCT02901431
4

NCT02179866

NCT01967979

NCT01708616

NCT01418963

Action Inhibit “Balovaptan is a potent, selective vasopressin 1a receptor antagonist.” PMID 34176392 Jul 2021
1

“Vasopressin V1a receptor antagonist” CHEMBL4297183

Modality Small molecule CHEMBL4297183
Route Oral “Following Oral Administration” NCT01418963
Target AVPR1A “Vasopressin V1a receptor antagonist” CHEMBL4297183