Drugs / J591 177LU
Trials 4 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 13 trials | ||||||
| Phase 1 | NCT00967577 | Jul 2009 → Jun 2018 | breast cancer, colorectal cancer, esophageal cancer, glioma +5 | Weill Medical College of Cornell University | Completed | No outcome recorded |
| Phase 1 | NCT00916123 | May 2009 → Dec 2015 | prostate cancer | Weill Medical College of Cornell University | Completed | No outcome recorded |
| Phase 1 | NCT00538668 | Aug 2007 → Oct 2015 | prostate cancer | Weill Medical College of Cornell University | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT00859781 | Jun 2009 → Feb 2022 overdue | prostate cancer | Weill Medical College of Cornell University | Active not recruiting | No outcome recorded |
Also used as a comparator or background therapy in 1 trial
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1/2 | NCT03545165 Background | Apr 2018 → Jul 2020 | prostate cancer | Weill Medical College of Cornell University | Terminated | No outcome recorded |
Evidence & citations 7 cited values
Every value below carries the sentence it was read from. 6 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | J591 177LU | ChEMBL registry synonym — accepted as the source's own label CHEMBL2109559 ↗ |
| Known as | 177Lu-J591 | “Radioimmunotherapy in Prostate Cancer Using 177Lu-J591 Antibody” NCT00538668 ↗ |
| Known as | HUJ591-GS | ChEMBL registry synonym — accepted as the source's own label CHEMBL2109559 ↗ |
| Action | Deplete | “deliver a lethal dose of radiation to the areas of cancer” NCT00916123 ↗ |
| Modality | Monoclonal antibody | “Following the administration of 177Lu-J591 mAb on day 0” NCT00538668 ↗ |
| Route | Intravenous | “177Lu-J591 \[1.35 GBq/m2 or 36.5 mCi/m2\] x2 doses, 2 weeks apart (Treatment Visit #1 and #2), IV administration” NCT03545165 ↗ |
| Target | FOLH1 | “Glutamate carboxypeptidase II binding agent” CHEMBL2109559 ↗ |