Drugs / Peretinoin
last change Feb 2024 re-read 3 minutes ago

Peretinoin

also known as NIK-333

Small molecule targets MYCN

Developed for
liver cancer
Investigated by
Kowa Company, Ltd.

Trials 1

2012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 3 NCT01640808 Apr 2012 → Oct 2016 liver cancer Kowa Company, Ltd. Completed Missed primary

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as Peretinoin ClinicalTrials.gov intervention name — accepted as the source's own label NCT01640808 ↗
Known as NIK-333 “NIK-333(peretinoin)” NCT01640808 ↗
Modality Small molecule “acyclic retinoid (ACR), an orally administered vitamin A derivative” PMID 38380807 ↗ Feb 2024
Route Oral “600mg (8 x 75mg capsules) orally, twice a day” NCT01640808 ↗
Target MYCN “The proto-oncogene MYCN expression marked a cancer stem-like cell population in hepatocellular carcinoma (HCC) and served as a therapeutic target of acyclic retinoid (ACR)” PMID 38380807 ↗ Feb 2024