Drugs / NERIGLIATIN
NERIGLIATIN
also known as
PF04937319 · N,N-dimethyl-5-((2-methyl-6-((5-methylpyrazin-2-yl)carbamoyl)benzofuran-4-yl)oxy)pyrimidine-2-carboxamide · Nerigliatina · Nerigliatine
Small molecule targets GCK via activation
Trials 9
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 17 trials | ||||||
| Phase 1 | NCT02292433 | Jan → Mar 2015 | type 2 diabetes mellitus | Pfizer | Completed | No outcome recorded |
| Phase 1 | NCT02206607 | Sep 2014 → Jan 2015 | type 2 diabetes mellitus | Pfizer | Completed | No outcome recorded |
| Phase 1 | NCT01933672 | Oct 2013 → Mar 2014 | type 2 diabetes mellitus | Pfizer | Completed | No outcome recorded |
| Phase 1 | NCT01513928 | Jan → Feb 2012 | — | Pfizer | Completed | No outcome recorded |
| Phase 1 | NCT01468714 | Oct 2011 | — | Pfizer | Completed | No outcome recorded |
| Phase 1 | NCT01272804 | Feb → Jul 2011 | type 2 diabetes mellitus | Pfizer | Completed | No outcome recorded |
| Phase 1 | NCT01044537 | Feb → May 2010 | type 2 diabetes mellitus | Pfizer | Completed | No outcome recorded |
| Phase 22 trials · 1 met primary | ||||||
| Phase 2 | NCT01517373 | Feb 2012 → Jan 2013 | type 2 diabetes mellitus | Pfizer | Completed | Met primary |
| Phase 2 | NCT01475461 | Nov 2011 → Jan 2013 | type 2 diabetes mellitus | Pfizer | Completed | No outcome recorded |
Evidence & citations 9 cited values
Every value below carries the sentence it was read from. 11 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | NERIGLIATIN | ChEMBL registry synonym — accepted as the source's own label CHEMBL2165615 ↗ |
| Known as | N,N-dimethyl-5-((2-methyl-6-((5-methylpyrazin-2-yl)carbamoyl)benzofuran-4-yl)oxy)pyrimidine-2-carboxamide | “The present article summarizes Metabolites in Safety Testing (MIST) studies on a glucokinase activator,...” PMID 25142735 ↗ Aug 2014 |
| Known as | Nerigliatina | ChEMBL registry synonym — accepted as the source's own label CHEMBL2165615 ↗ |
| Known as | Nerigliatine | ChEMBL registry synonym — accepted as the source's own label CHEMBL2165615 ↗ |
| Known as | PF04937319 | “The purpose of this phase 1 study is to characterize the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF04937319 following single escalating oral doses in...” NCT01044537 ↗ |
| Action | Activate | “Hexokinase type IV activator” CHEMBL2165615 ↗1“a glucokinase activator” PMID 25142735 ↗ Aug 2014 |
| Modality | Small molecule | — CHEMBL2165615 ↗ |
| Route | Oral | “All doses will be administered as a single oral dose as a powder-in-capsule (PIC) formulation.” NCT01044537 ↗ |
| Target | GCK | “Hexokinase type IV activator” CHEMBL2165615 ↗ |