drugset
Drugs / ABT-126
last change Jun 2015 re-read 2 minutes ago

ABT-126

also known as Nelonicline

Small molecule targets CHRNA7 via activation

Developed for
Alzheimer disease · schizophrenia
Investigated by
AbbVie · Abbott · AbbVie

Trials 13 · a red edge is where a trial was stopped

today NCT01834638 · Ph 2 NCT01690195 · Ph 2 NCT01676935 · Ph 2 NCT01678755 · Ph 2 NCT01655680 · Ph 2 NCT01549834 · Ph 2 NCT01527916 · Ph 2 NCT01482845 · Ph 1 NCT01095562 · Ph 2 NCT01043458 · Ph 1 NCT00948909 · Ph 2 NCT00959634 · Ph 1 NCT00912431 · Ph 1
2009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT01482845 Nov 2011 → Mar 2012 Alzheimer disease Abbott Completed No outcome recorded
Phase 1 NCT01043458 Nov 2009 → Jan 2010 schizophrenia Abbott Completed No outcome recorded
Phase 1 NCT00959634 Aug → Sep 2009 — Abbott Completed No outcome recorded
Phase 1 NCT00912431 Jun → Aug 2009 — Abbott Completed No outcome recorded
Phase 29 trials
Phase 2 NCT01834638 Mar 2013 → Nov 2014 schizophrenia AbbVie Terminated No outcome recorded
Phase 2 NCT01690195 Sep 2012 → Feb 2014 Alzheimer disease AbbVie Terminated No outcome recorded
Phase 2 NCT01676935 Aug 2012 → Mar 2014 Alzheimer disease AbbVie Terminated No outcome recorded
Phase 2 NCT01678755 Aug 2012 → Mar 2014 schizophrenia AbbVie Completed No outcome recorded
Phase 2 NCT01655680 May 2012 → Apr 2014 schizophrenia AbbVie Completed No outcome recorded
Phase 2 NCT01549834 Mar 2012 → Oct 2013 Alzheimer disease AbbVie Completed No outcome recorded
Phase 2 NCT01527916 Feb 2012 → Nov 2013 Alzheimer disease AbbVie Completed No outcome recorded
Phase 2 NCT01095562 Mar 2010 → Aug 2011 — AbbVie Completed No outcome recorded
Phase 2 NCT00948909 Oct 2009 → Nov 2010 Alzheimer disease AbbVie Completed No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT00867399 Comparator Mar → May 2009 Alzheimer disease Abbott Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 16 sources stand behind the page.

FieldValueCited text
Known as ABT-126 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01043458 ↗
13

NCT01690195 ↗

NCT00959634 ↗

NCT01676935 ↗

NCT01095562 ↗

NCT01678755 ↗

NCT01655680 ↗

NCT01834638 ↗

NCT00948909 ↗

NCT01527916 ↗

NCT00867399 ↗

NCT01482845 ↗

NCT01549834 ↗

NCT00912431 ↗
Known as Nelonicline ChEMBL registry synonym — accepted as the source's own label CHEMBL3545231 ↗
Action Activate “Neuronal acetylcholine receptor protein alpha-7 subunit agonist” CHEMBL3545231 ↗
1

“novel α7 nicotinic acetylcholine receptor agonist ABT-126” PMID 29854928 ↗ Jun 2015
Modality Small molecule — CHEMBL3545231 ↗
Target CHRNA7 “Neuronal acetylcholine receptor protein alpha-7 subunit agonist” CHEMBL3545231 ↗