Drugs / Relamorelin
last change Nov 2020 re-read 3 minutes ago

Relamorelin

also known as BIM-28131 · Relamorelina · Relamoreline

Peptide targets GHSR via activation

Developed for
gastroparesis · diabetes mellitus
Investigated by
Allergan

Trials 6

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 21 trial · 1 missed
Phase 2 NCT02357420 Jan 2015 → Jun 2016 diabetes mellitus, gastroparesis Allergan Completed Missed primary
Phase 35 trials
Phase 3 NCT03786380 Dec 2018 → Oct 2020 gastroparesis Allergan Terminated No outcome recorded Stop: Business
Phase 3 NCT03426345 Feb 2018 → Jul 2020 diabetes mellitus, gastroparesis Allergan Terminated No outcome recorded Stop: Business
Phase 3 NCT03383146 Feb 2018 → Nov 2020 diabetes mellitus, gastroparesis Allergan Terminated No outcome recorded Stop: Business
Phase 3 NCT03420781 Jan 2018 → Oct 2020 diabetes mellitus, gastroparesis Allergan Terminated No outcome recorded Stop: Business
Phase 3 NCT03285308 Sep 2017 → Jul 2020 diabetes mellitus, gastroparesis Allergan Terminated No outcome recorded Stop: Business
Comparator or background therapy1 trial
Phase 1 NCT02466711 Comparator Jun → Aug 2015 intestinal dysmotility syndrome Motus Therapeutics, Inc. Completed No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 10 sources stand behind the page.

FieldValueCited text
Known as Relamorelin ClinicalTrials.gov intervention name — accepted as the source's own label NCT02357420 ↗
6

NCT02466711 ↗

NCT03420781 ↗

NCT03786380 ↗

NCT03426345 ↗

NCT03383146 ↗

NCT03285308 ↗

Known as BIM-28131 ChEMBL registry synonym — accepted as the source's own label CHEMBL4297525 ↗
Known as Relamorelina ChEMBL registry synonym — accepted as the source's own label CHEMBL4297525 ↗
Known as Relamoreline ChEMBL registry synonym — accepted as the source's own label CHEMBL4297525 ↗
Action Activate “a selective, prokinetic agonist of ghrelin” PMID 28760384 ↗ Jul 2017
1

“Ghrelin receptor agonist” CHEMBL4297525 ↗

Modality Peptide “a pentapeptide ghrelin receptor agonist” PMID 32301137 ↗ Apr 2020
Route Subcutaneous “Study drug (relamorelin and placebo) will be administered subcutaneously in a blinded fashion.” NCT02357420 ↗
Target GHSR “Ghrelin receptor agonist” CHEMBL4297525 ↗