Drugs / MK0916
last change Jun 2011 re-read 2 minutes ago

MK0916

targets HSD11B1 via inhibition

Developed for
hypertensive disorder · metabolic syndrome X · type 2 diabetes mellitus
Investigated by
Merck Sharp & Dohme LLC

Trials 2 · a red edge is where a trial was stopped

200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT00274716 Nov 2005 → Jan 2007 hypertensive disorder Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 2 NCT00543595 Aug 2004 → May 2005 metabolic syndrome X, type 2 diabetes mellitus Merck Sharp & Dohme LLC Completed No outcome recorded

Evidence & citations 3 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as MK-0916 “This study evaluated the antihypertensive efficacy and safety of two 11β-HSD1 inhibitors, MK-0736 and MK-0916, in overweight-to-obese hypertensive patients.” PMID 21419745 Mar 2011
3

“Effects of an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, MK-0916, in patients with type 2 diabetes mellitus and metabolic syndrome.” PMID 21272190 Jun 2011

NCT00274716

NCT00543595

Action Inhibit “two 11β-HSD1 inhibitors” PMID 21419745 Mar 2011
Target HSD11B1 “This study evaluated the antihypertensive efficacy and safety of two 11β-HSD1 inhibitors, MK-0736 and MK-0916, in overweight-to-obese hypertensive patients.” PMID 21419745 Mar 2011