CYCLOGUANIL

also known as Malarone · Atovaquone-proguanil · CHLORCYCLOGUANIL HYDROCHLORIDE · Chloroguanide triazine pamoate · CI-501 · CN-14,329-23A · Cycloguanil embonate · CYCLOGUANIL PAMOATE · +4 more

Small molecule

Developed for: Plasmodium falciparum malaria
Investigated by: National Institute of Allergy and Infectious Diseases (NIAID) · Walter Reed Army Institute of Research (WRAIR)

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Approved	US (FDA)	MALARONE PEDIATRIC	—	2000-07-14	fda.gov ↗

Trials 2 · a red edge is where a trial was stopped

today

US approved 2000

NCT03991208 · Ph 4 NCT00379821 · Ph 3

2000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 31 trial
Phase 3	NCT00379821	Feb 2007 → Aug 2009	Plasmodium falciparum malaria	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded
Phase 41 trial
Phase 4	NCT03991208	May 2019 → May 2021	—	Walter Reed Army Institute of Research (WRAIR)	Withdrawn	No outcome recorded

Also used as a comparator or background therapy in 4 trials

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 22 trials
Phase 2	NCT03278808 Background	Sep 2018 → Dec 2019	malaria	U.S. Army Medical Research and Development Command	Withdrawn	No outcome recorded
Phase 2	NCT00298610 Background	Mar 2006 → Oct 2007	malaria	U.S. Army Medical Research and Development Command	Completed	No outcome recorded
Phase not applicable2 trials
—	NCT01422954 Background	Jan → Dec 2012	Plasmodium falciparum malaria	Radboud University Medical Center	Completed	No outcome recorded
—	NCT01236612 Background	Apr 2011 → Jun 2012	Plasmodium falciparum malaria	Radboud University Medical Center	Completed	No outcome recorded

Evidence & citations 14 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

Field	Value	Cited text
Known as	CYCLOGUANIL	ChEMBL registry synonym — accepted as the source's own label CHEMBL747 ↗
Known as	Atovaquone-proguanil	ClinicalTrials.gov intervention name — accepted as the source's own label NCT00379821 ↗ 1 NCT03278808 ↗
Known as	CHLORCYCLOGUANIL HYDROCHLORIDE	ChEMBL registry synonym — accepted as the source's own label CHEMBL747 ↗
Known as	Chloroguanide triazine pamoate	ChEMBL registry synonym — accepted as the source's own label CHEMBL747 ↗
Known as	CI-501	ChEMBL registry synonym — accepted as the source's own label CHEMBL747 ↗
Known as	CN-14,329-23A	ChEMBL registry synonym — accepted as the source's own label CHEMBL747 ↗
Known as	Cycloguanil embonate	ChEMBL registry synonym — accepted as the source's own label CHEMBL747 ↗
Known as	CYCLOGUANIL PAMOATE	ChEMBL registry synonym — accepted as the source's own label CHEMBL747 ↗
Known as	Embonate de cycloguanil	ChEMBL registry synonym — accepted as the source's own label CHEMBL747 ↗
Known as	Embonato de cicloguanil	ChEMBL registry synonym — accepted as the source's own label CHEMBL747 ↗
Known as	Malarone	“A standard dose of atovaquone-proguanil (Malarone®) will be administered to all symptomatic parasitemic subjects under directly observed treatment.” NCT03278808 ↗ 4 “Following completion of Artesunate treatment, all subjects received Malarone follow-on therapy to ensure parasitologic cure.” NCT00298610 ↗ NCT01422954 ↗ NCT01236612 ↗ NCT03991208 ↗
Known as	NSC-77830	ChEMBL registry synonym — accepted as the source's own label CHEMBL747 ↗
Known as	PAM-MR-807-23A	ChEMBL registry synonym — accepted as the source's own label CHEMBL747 ↗
Modality	Small molecule	— CHEMBL747 ↗