Drugs / galeterone
last change Dec 2019 re-read 2 minutes ago

galeterone

also known as Galeterona · TOK-001 · VN 124 · VN/124-1

Small molecule targets AR, CYP17A1 via inhibition

Developed for
prostate cancer · pancreatic neoplasm
Investigated by
LTN PHARMACEUTICALS, INC. · University of Maryland, Baltimore

Trials 5 · a red edge is where a trial was stopped

201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT02729376 Mar → Apr 2016 LTN PHARMACEUTICALS, INC. Completed No outcome recorded
Phase 1 NCT00959959 Oct 2009 → Aug 2011 prostate cancer LTN PHARMACEUTICALS, INC. Completed No outcome recorded
Phase 22 trials
Phase 2 NCT04098081 Dec 2019 → Dec 2026 expected pancreatic neoplasm University of Maryland, Baltimore Active not recruiting No outcome recorded
Phase 2 NCT01709734 Dec 2012 → Sep 2016 prostate cancer LTN PHARMACEUTICALS, INC. Terminated No outcome recorded
Phase 31 trial
Phase 3 NCT02438007 Jun 2015 → Jul 2016 prostate cancer LTN PHARMACEUTICALS, INC. Terminated No outcome recorded

Evidence & citations 10 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as Galeterone ClinicalTrials.gov intervention name — accepted as the source's own label NCT02438007
3

NCT02729376

NCT04098081

NCT01709734

Known as Galeterona ChEMBL registry synonym — accepted as the source's own label CHEMBL2105738
Known as TOK-001 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00959959
Known as VN 124 ChEMBL registry synonym — accepted as the source's own label CHEMBL2105738
Known as VN/124-1 ChEMBL registry synonym — accepted as the source's own label CHEMBL2105738
Action Inhibit “Galeterone is an androgen receptor inhibitor” NCT04098081
2

“Cytochrome P450 17A1 inhibitor” CHEMBL2105738

“Androgen Receptor antagonist” CHEMBL2105738

Modality Small molecule CHEMBL2105738
Route Oral “galeterone tablets once daily PO for three months + extension” NCT01709734
Target AR “Androgen Receptor antagonist” CHEMBL2105738
Target CYP17A1 “Cytochrome P450 17A1 inhibitor” CHEMBL2105738