Drugs / Zuretinol Acetate

Trials 5

2009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT01543906 Feb 2012 → Jul 2014 retinitis pigmentosa QLT Inc. Completed No outcome recorded
Phase 1 NCT01521793 Jan 2012 → May 2014 Leber congenital amaurosis, retinitis pigmentosa QLT Inc. Completed No outcome recorded
Phase 1 NCT01014052 Nov 2009 → Aug 2012 Leber congenital amaurosis, retinitis pigmentosa QLT Inc. Completed No outcome recorded
Phase 1 NCT00765427 Sep 2008 → Mar 2009 — QLT Inc. Completed No outcome recorded
Phase 21 trial
Phase 2 NCT01999764 Nov 2013 → Jun 2014 night blindness QLT Inc. Completed No outcome recorded
Comparator or background therapy1 trial
Phase 2/3 NCT04311112 Comparator Dec 2020 → Feb 2023 retinal disorder Retinagenix Holdings Withdrawn No outcome recorded

News releases announcing trial results or a regulatory action · 4

DateIssuerRelease
2014-12-05 QLT Inc. Results QLT Announces Results From Proof-of-Concept Trial With Oral Synthetic cis-Retinoid (QLT091001) In Adult Subjects With Impaired Dark Adaptation and/or Impaired Low Luminance Vision qltinc.com ↗
QLT Inc. (Nasdaq:QLTI) (TSX:QLT) (“QLT” or the “Company”) today announced results from its multi-center, Phase 2a clinical trial of repeated treatments of oral QLT091001 in adult subjects with early age-related macular degeneration (AMD) and impaired dark adaptation and/or impaired low luminance vision.
2014-09-12 QLT Inc. Results QLT Announces Positive Final Results from Phase 1b Retreatment Trial with Oral Synthetic cis-Retinoid (QLT091001) in Subjects with LCA or RP Due to Mutations in RPE65 or LRAT qltinc.com ↗
Also, there appears to be a small, but positive effect on visual acuity in both patient groups.
2014-07-14 QLT Inc. Results QLT Announces Publication in The Lancet of Phase 1b Data for QLT091001 in Leber Congenital Amaurosis due to LRAT or RPE65 Mutations qltinc.com ↗
2014-02-27 QLT Inc. Results QLT Announces Positive Preliminary Results from Phase 1b Retreatment Trial of QLT091001 in Subjects with Leber Congenital Amaurosis and Retinitis Pigmentosa Due to Mutations in LRAT or RPE65 qltinc.com ↗
Preliminary results of this Phase 1b study showed clinical ly meaningful improvements in visual fields (VF) and visual acuity (VA).

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as Zuretinol Acetate “Safety and Efficacy of Zuretinol Acetate in Subjects With Inherited Retinal Disease” NCT04311112 ↗
Known as 9-cis-retinal acetate ChEMBL registry synonym — accepted as the source's own label CHEMBL4297637 ↗
Known as 9-cis-retinyl acetate “with oral QLT091001 (synthetic 9-cis-retinyl acetate) in these patients.” PMID 25030840 ↗ Jul 2014
Known as 9-cis-vitamin a acetate ChEMBL registry synonym — accepted as the source's own label CHEMBL4297637 ↗
Known as 9-cis-vitamin a1 acetate ChEMBL registry synonym — accepted as the source's own label CHEMBL4297637 ↗
Known as Acetate de zuretinol ChEMBL registry synonym — accepted as the source's own label CHEMBL4297637 ↗
Known as Acetato de zuretinol ChEMBL registry synonym — accepted as the source's own label CHEMBL4297637 ↗
Known as QLT091001 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01999764 ↗
4

NCT01543906 ↗

NCT00765427 ↗

NCT01014052 ↗

NCT01521793 ↗

Action Restore “We aimed to assess replacement of the missing chromophore 11-cis retinal with oral QLT091001” PMID 25030840 ↗ Jul 2014
Modality Small molecule — CHEMBL4297637 ↗
Route Oral “oral QLT091001 administered once daily for 7 days” NCT01014052 ↗