Drugs / GT103
last change Apr 2026 re-read 3 minutes ago

GT103

Monoclonal antibody targets CFH

Developed for
non-small cell lung carcinoma
Investigated by
Edward Patz · Grid Therapeutics · Jeffrey Clarke · Merck Sharp & Dohme LLC · Roswell Park Cancer Institute

Trials 3

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial · 1 met primary
Phase 1 NCT04314089 Jun 2020 → Apr 2024 non-small cell lung carcinoma Edward Patz Completed Met primary
Phase 22 trials
Phase 2 NCT07017829 Apr 2026 → Dec 2028 expected non-small cell lung carcinoma Roswell Park Cancer Institute Recruiting No outcome recorded
Phase 2 NCT05617313 Feb 2023 → Jun 2025 non-small cell lung carcinoma Jeffrey Clarke Terminated No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as GT103 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04314089 ↗
2

NCT05617313 ↗

NCT07017829 ↗

Modality Monoclonal antibody “fully human, IgG3 monoclonal antibody” PMID 39747856 ↗ Jan 2025
Route Intravenous “GT103 given intravenously at 0.3, 1, 3, 10, and 15 mg/kg every 3 weeks” PMID 39747856 ↗ Jan 2025
Target CFH “GT103 is a first-in-class, fully human, IgG3 monoclonal antibody targeting complement factor H” PMID 39747856 ↗ Jan 2025