Drugs / veledimex
veledimex
Trials 10 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 14 trials | ||||||
| Phase 1 | NCT03679754 | Sep 2018 → Apr 2019 | glioblastoma | Alaunos Therapeutics | Completed | No outcome recorded |
| Phase 1 | NCT03636477 | Jun 2018 → Oct 2020 | glioblastoma | Alaunos Therapeutics | Completed | No outcome recorded |
| Phase 1 | NCT02026271 | Jun 2015 → Aug 2019 | anaplastic oligoastrocytoma, glioblastoma | Alaunos Therapeutics | Completed | No outcome recorded |
| Phase 1 | NCT00815607 | Apr 2009 → Jan 2013 | melanoma | Alaunos Therapeutics | Completed | No outcome recorded |
| Phase 1/24 trials | ||||||
| Phase 1/2 | NCT03740724 | Dec 2019 → Sep 2020 | localized scleroderma | Castle Creek Biosciences, LLC. | Terminated | No outcome recorded |
| Phase 1/2 | NCT03330197 | Sep 2017 → Sep 2021 | diffuse intrinsic pontine glioma | Alaunos Therapeutics | Terminated | No outcome recorded |
| Phase 1/2 | NCT02423902 | Jul 2015 → Jul 2016 | breast cancer | Alaunos Therapeutics | Terminated | No outcome recorded |
| Phase 1/2 | NCT01397708 | Aug 2011 → Sep 2014 | melanoma | Alaunos Therapeutics | Completed | No outcome recorded |
| Phase 22 trials | ||||||
| Phase 2 | NCT04006119 | Aug 2019 → Aug 2021 | glioblastoma | Alaunos Therapeutics | Terminated | No outcome recorded |
| Phase 2 | NCT01703754 | Apr 2013 → Aug 2014 | breast carcinoma | Alaunos Therapeutics | Terminated | No outcome recorded |
Evidence & citations 7 cited values
Every value below carries the sentence it was read from. 13 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | veledimex | ClinicalTrials.gov intervention name — accepted as the source's own label NCT03636477 ↗ |
| Known as | INXN-1001 | “evaluating the safety and efficacy of INXN-1001 (veledimex) and INXN-2001 (Ad-RTS-hIL-12) alone and in combination with palifosfamide.” NCT01703754 ↗ |
| Known as | RG-115932 | ChEMBL registry synonym — accepted as the source's own label CHEMBL3039523 ↗ |
| Known as | VDX | “Veledimex (VDX)-regulatable interleukin-12 (IL-12) gene therapy in recurrent glioblastoma (rGBM) was reported to show tumor infiltration of CD8+ T cells, encouraging survival,...” PMID 34850166 ↗ Jun 20221“The oral activator for hIL-12, veledimex (VDX), was administered preoperatively” PMID 31413142 ↗ Aug 2019 |
| Action | Activate | “Oral activator ligand” NCT01703754 ↗ |
| Modality | Small molecule | “Veledimex, is a small molecule which activates the RTS to induce expression of MMP-1” NCT03740724 ↗ |
| Route | Oral | “oral Activator Ligand administration” NCT00815607 ↗ |