Drugs / DC vaccine
DC vaccine
also known as
DC Vaccine ( Dendritic cell vaccine) · Dendritic Cell Vaccine - DC Vaccine · Neo-DC vaccine · αDC1
Trials 23
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 16 trials | ||||||
| Phase 1 | NCT04999943 | Jul 2021 → Jul 2026 | myelodysplastic syndrome | Affiliated Hospital to Academy of Military Medical Sciences | Unknown | No outcome recorded |
| Phase 1 | NCT04147078 | Jun 2019 → Dec 2025 overdue | colorectal cancer, gastric cancer, hepatocellular carcinoma, non-small cell lung carcinoma | Sichuan University | Recruiting | No outcome recorded |
| Phase 1 | NCT03730948 | Mar 2019 → Feb 2022 | colorectal cancer | University of Pennsylvania | Terminated | No outcome recorded Stop: Enrollment |
| Phase 1 | NCT02956551 | Nov 2016 → Dec 2019 | non-small cell lung carcinoma | Sichuan University | Unknown | No outcome recorded |
| Phase 1 | NCT01671592 | Jan 2013 → Apr 2014 | colorectal carcinoma | Pawel Kalinski | Completed | No outcome recorded |
| Phase 1 | NCT00978913 | Sep 2009 → Aug 2013 | breast cancer, melanoma | Inge Marie Svane | Completed | No outcome recorded |
| Phase 1/28 trials | ||||||
| Phase 1/2 | NCT04567069 | Sep 2020 → Dec 2021 | gastric cancer | The Second Hospital of Shandong University | Unknown | No outcome recorded |
| Phase 1/2 | NCT02432378 | Sep 2015 → Jun 2025 | ovarian cancer | Roswell Park Cancer Institute | Withdrawn | No outcome recorded |
| Phase 1/2 | NCT02688673 | Aug 2014 → Aug 2016 | small cell lung carcinoma | Affiliated Hospital to Academy of Military Medical Sciences | Unknown | No outcome recorded |
| Phase 1/2 | NCT02151448 | Jul 2014 → Feb 2019 | malignant pancreatic neoplasm, malignant peritoneal mesothelioma, peritoneal carcinomatosis | David Bartlett | Completed | No outcome recorded |
| Phase 1/2 | NCT02543749 | Jul 2014 → Jul 2022 | chronic myeloid leukemia | Charite University, Berlin, Germany | Terminated | No outcome recorded |
| Phase 1/2 | NCT02018458 | May 2014 → Sep 2019 | breast cancer | Baylor Research Institute | Completed | No outcome recorded |
| Phase 1/2 | NCT00862303 | Mar 2009 → Jun 2015 | renal cell carcinoma | Fuzhou General Hospital | Unknown | No outcome recorded |
| Phase 1/2 | NCT00313235 | Mar 2006 → Jun 2011 | melanoma | Baylor Research Institute | Completed | No outcome recorded |
| Phase 26 trials | ||||||
| Phase 2 | NCT02334735 | Jul 2015 → Jul 2020 | melanoma | Nina Bhardwaj | Completed | No outcome recorded |
| Phase 2 | NCT01876212 | May 2014 → Jul 2018 | metastatic melanoma | Walter J. Storkus | Completed | No outcome recorded |
| Phase 2 | NCT01686334 | Oct 2012 → Dec 2025 overdue | acute myeloid leukemia | Zwi Berneman | Active not recruiting | No outcome recorded |
| Phase 2 | NCT00935558 | Jul 2009 → May 2012 | breast cancer | Inge Marie Svane | Withdrawn | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT00913913 | Feb 2009 → Jan 2013 | renal cell carcinoma | Dartmouth-Hitchcock Medical Center | Terminated | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT00722098 | Jun 2008 → Apr 2011 | metastatic melanoma | Baylor Research Institute | Terminated | No outcome recorded Stop: Enrollment |
| Phase not applicable3 trials | ||||||
| — | NCT06682117 | Nov 2024 → Dec 2026 expected | — | Fudan University | Recruiting | No outcome recorded |
| — | NCT05000801 | Jul 2021 → Jul 2026 | acute myeloid leukemia | Affiliated Hospital to Academy of Military Medical Sciences | Unknown | No outcome recorded |
| — | NCT00327496 | Jun 2005 → Jun 2006 | hepatocellular carcinoma | Mackay Memorial Hospital | Unknown | No outcome recorded |
| Comparator or background therapy1 trial | ||||||
| Phase 1 | NCT02548169 Comparator | Aug 2015 → Apr 2017 | malignant pancreatic neoplasm | Baylor Research Institute | Terminated | No outcome recorded Stop: Business |
Evidence & citations 9 cited values
Every value below carries the sentence it was read from. 24 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | DC vaccine | “autologous dendritic cells (DC) loaded with autologous tumor lysate (DC vaccine)” NCT00862303 ↗ |
| Known as | DC Vaccine ( Dendritic cell vaccine) | “DC Vaccine ( Dendritic cell vaccine)” NCT00722098 ↗1“DC Vaccine - Dendritic Cell Vaccine” NCT02018458 ↗ |
| Known as | Dendritic Cell Vaccine - DC Vaccine | “Dendritic Cell Vaccine - DC Vaccine” NCT00313235 ↗ |
| Known as | Neo-DC vaccine | “This is a clinical study of personalized self-DC vaccine targeting neo-antigen (Neo-DC vaccine) in the treatment of advanced solid tumors.” NCT06682117 ↗ |
| Known as | αDC1 | “intradermal (ID) autologous αDC1 vaccines (known to be nontoxic)” NCT02432378 ↗ |
| Action | Deplete | “dendritic cell vaccination can significantly prevent relapse and increase survival of AML patients by eradicating minimal residual disease” NCT01686334 ↗ |
| Modality | Vaccine | “dendritic cell vaccine” NCT00313235 ↗ |
| Route | Subcutaneous | “will be injected subcutaneously” NCT00313235 ↗ |
| Target | WT1 | “loaded by messenger RNA electroporation with the Wilms' tumor antigen (WT1)” NCT01686334 ↗ |