Drugs / Varivax
last change Jun 2026 re-read 2 minutes ago

Varivax

Vaccine

Developed for
herpes zoster · chickenpox · measles · mumps infectious disease · rubella · varicella zoster infection · disease related to solid organ transplantation · human papilloma virus infection
+2 more · postherpetic neuralgia · systemic lupus erythematosus
Investigated by
Merck Sharp & Dohme LLC · National Institute of Allergy and Infectious Diseases (NIAID) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · GlaxoSmithKline · Oklahoma Medical Research Foundation · Sanofi Pasteur, a Sanofi Company
+29 more · Seoul National University Hospital · University of Colorado, Denver · Adult AIDS Clinical Trials Group · Bristol-Myers Squibb · Cooperative Clinical Trials in Pediatric Transplantation · Duke University · Emory University · HaEmek Medical Center, Israel · Indiana University · Innovaderm Research Inc. · Jiangsu Province Centers for Disease Control and Prevention · Kevin Winthrop · Memorial Sloan Kettering Cancer Center · Moi University · NIAID Vaccine and Treatment Evaluation Units (VTEUs) · National Institute on Aging (NIA) · North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) · Rockefeller University · SK Bioscience Co., Ltd. · Shanghai Institute Of Biological Products · Stanford University · The University of Hong Kong · US Department of Veterans Affairs · University of Alabama at Birmingham · University of Alberta · University of South Florida · University of Sydney · University of Washington · University of Zurich

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved EU (EMA) ProQuad 2006-04-05 europa.eu

Trials 55 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 18 trials
Phase 1 NCT01506661 Jan 2012 → Dec 2017 rheumatoid arthritis, varicella zoster infection Oklahoma Medical Research Foundation Completed No outcome recorded
Phase 1 NCT01474720 Nov 2011 → Jul 2012 systemic lupus erythematosus Oklahoma Medical Research Foundation Completed No outcome recorded
Phase 1 NCT01385566 Sep 2011 → May 2013 herpes zoster Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT01262300 Nov 2010 → Jan 2014 herpes zoster, immune system disorder University of Colorado, Denver Completed No outcome recorded
Phase 1 NCT01137669 Sep 2010 → Feb 2015 herpes zoster National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT00005009 Feb 1998 → Jun 2001 disease related to solid organ transplantation National Institute of Allergy and Infectious Diseases (NIAID) Terminated No outcome recorded
Phase 1 NCT00001125 ? → Mar 2004 HIV infectious disease, chickenpox National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT00000837 ? → Nov 2005 HIV infectious disease National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT04072497 Nov 2018 → Apr 2020 herpes zoster Shanghai Institute Of Biological Products Completed No outcome recorded
Phase 1/2 NCT01213810 Dec 2010 → Dec 2011 herpes zoster University of Zurich Withdrawn No outcome recorded
Phase 1/2 NCT00258726 Oct 2005 → Jul 2007 chickenpox, measles, mumps infectious disease, rubella National Institute of Allergy and Infectious Diseases (NIAID) Terminated No outcome recorded
Phase 28 trials
Phase 2 NCT04398706 May 2020 → Aug 2023 chickenpox, diphtheria, haemophilus meningitis, hepatitis B virus infection +6 Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 2 NCT03604406 May 2014 → Jun 2024 herpes zoster, rheumatoid arthritis Kevin Winthrop Completed No outcome recorded
Phase 2 NCT01573182 Apr 2012 → May 2018 herpes zoster University of Sydney Completed No outcome recorded
Phase 2 NCT01049035 Dec 2009 → Feb 2012 meningitis, meningococcal infection Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 2 NCT00851786 Apr 2009 → Sep 2011 HIV infectious disease, herpes zoster National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 2 NCT00546819 Oct 2007 → Aug 2010 herpes zoster Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 2 NCT00505063 Jul 2007 → Jun 2025 childhood malignant neoplasm Memorial Sloan Kettering Cancer Center Completed No outcome recorded
Phase 2 NCT00109122 Nov 2001 → Feb 2003 herpes zoster Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT02329457 Dec 2014 → Sep 2019 varicella zoster infection The University of Hong Kong Completed No outcome recorded
Phase 320 trials
Phase 3 NCT07415252 Jun 2026 → Feb 2027 expected chickenpox SK Bioscience Co., Ltd. Not yet recruiting No outcome recorded
Phase 3 NCT03893448 Jun 2019 → May 2021 pneumococcal infection Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT03843632 Mar 2019 → Jun 2020 chickenpox Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT03314103 Oct 2017 → Jan 2019 herpes zoster Jiangsu Province Centers for Disease Control and Prevention Completed No outcome recorded
Phase 3 NCT02519855 Sep 2015 → Jan 2016 herpes zoster Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT01527370 Oct 2012 → Apr 2013 herpes zoster Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT01391546 Jun 2011 → Oct 2012 herpes zoster Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT01245751 Apr 2011 → Jul 2012 herpes zoster Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT00871117 Mar 2009 → Jan 2010 diphtheria, tetanus GlaxoSmithKline Completed No outcome recorded
Phase 3 NCT00561080 Oct 2007 → Jun 2009 herpes zoster Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 49 trials
Phase 4 NCT03016884 Jan 2017 → Sep 2019 herpes zoster HaEmek Medical Center, Israel Unknown No outcome recorded
Phase 4 NCT02408159 Jun 2016 → Jan 2017 psoriasis Innovaderm Research Inc. Terminated No outcome recorded
Phase 4 NCT02624375 Feb 2016 → Nov 2019 herpes zoster University of Washington Completed No outcome recorded
Phase 4 NCT01556451 Apr → Oct 2012 herpes zoster Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 4 NCT01911065 Sep 2010 → Dec 2011 herpes zoster Stanford University Completed No outcome recorded
Phase 4 NCT00940940 Oct 2009 → Aug 2013 University of Alberta Completed No outcome recorded
Phase 4 NCT00681031 May → Jun 2008 herpes zoster Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 4 NCT00550745 Sep 2007 → Jan 2009 herpes zoster Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 4 NCT00432731 Dec 2004 → Sep 2005 chickenpox, measles, mumps infectious disease, rubella Merck Sharp & Dohme LLC Completed No outcome recorded
Phase not applicable6 trials
NCT04774887 Nov 2021 → Oct 2023 HIV infectious disease, human papilloma virus infection Indiana University Completed No outcome recorded
NCT03192319 Jul 2017 → Aug 2018 herpes zoster Seoul National University Hospital Completed No outcome recorded
NCT02704572 Mar 2016 → Aug 2017 herpes zoster Seoul National University Hospital Completed No outcome recorded
NCT02960399 Dec 2015 → Dec 2017 Bruton-type agammaglobulinemia, common variable immunodeficiency, immunodeficiency due to selective anti-polysaccharide antibody deficiency University of South Florida Terminated No outcome recorded
NCT02590068 Dec 2015 → Sep 2017 chronic hepatitis C virus infection Rockefeller University Terminated No outcome recorded
NCT01331161 Jul 2011 → Apr 2012 herpes zoster Emory University Completed No outcome recorded
Also used as a comparator or background therapy in 47 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 15 trials
Phase 1 NCT02367638 Comparator Mar → Jul 2015 chickenpox Green Cross Corporation Completed No outcome recorded
Phase 1 NCT02114333 Comparator May 2014 → Mar 2016 herpes zoster University of Colorado, Denver Completed No outcome recorded
Phase 1 NCT01953900 Background Apr 2014 → Oct 2019 overdue neuroblastoma, osteosarcoma Baylor College of Medicine Active not recruiting No outcome recorded
Phase 1 NCT03121638 Comparator Nov 2012 → Feb 2013 varicella zoster infection SK Chemicals Co., Ltd. Completed No outcome recorded
Phase 1 NCT00886613 Comparator Mar → Dec 2009 herpes zoster Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT06851832 Comparator Feb 2025 → Sep 2026 expected herpes zoster Ab&B Bio-tech Co., Ltd.JS Active not recruiting No outcome recorded
Phase 26 trials
Phase 2 NCT05422508 Comparator Jul 2022 → Jun 2025 overdue chickenpox Green Cross Corporation Recruiting No outcome recorded
Phase 2 NCT05084508 Comparator Feb 2022 → Feb 2024 chickenpox GlaxoSmithKline Completed No outcome recorded
Phase 2 NCT02538341 Comparator May 2016 → Dec 2019 Crohn disease, ankylosing spondylitis, psoriasis, psoriatic arthritis University of Alabama at Birmingham Completed No outcome recorded
Phase 2 NCT03114982 Comparator May → Jul 2016 chickenpox SK Chemicals Co., Ltd. Completed No outcome recorded
Phase 2 NCT00861744 Background Jun 2009 → Jul 2010 measles, mumps infectious disease, rubella GlaxoSmithKline Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT03116594 Comparator Jan → Apr 2014 herpes zoster SK Chemicals Co., Ltd. Completed No outcome recorded
Phase 331 trials
Phase 3 NCT07054099 Comparator Mar 2026 → Aug 2027 expected chickenpox GC Biopharma Corp Recruiting No outcome recorded
Phase 3 NCT06975878 Background May 2025 → Aug 2027 expected Sanofi Active not recruiting No outcome recorded
Phase 3 NCT06855160 Comparator Apr 2025 → Sep 2026 expected chickenpox GlaxoSmithKline Recruiting No outcome recorded
Phase 3 NCT06824181 Background Feb 2025 → Sep 2027 expected Sanofi Active not recruiting No outcome recorded
Phase 3 NCT06824194 Background Feb 2025 → Oct 2027 expected Sanofi Active not recruiting No outcome recorded
Phase 43 trials
Phase 4 NCT02477150 Comparator Nov 2015 → Nov 2018 systemic lupus erythematosus Tuen Mun Hospital Completed No outcome recorded
Phase 4 NCT02444936 Comparator May 2015 → May 2018 herpes zoster Louis Stokes VA Medical Center Unknown No outcome recorded
Phase 4 NCT02958345 Comparator Jun 2013 → Jul 2015 herpes zoster Tulane University Completed No outcome recorded

Evidence & citations 27 cited values

Every value below carries the sentence it was read from. 109 sources stand behind the page.

FieldValueCited text
Known as Varivax “A Phase 3a, Open-Label, Randomized, Controlled Study to Evaluate the Immunogenicity and Safety of Intramuscular Administration of an Investigational Varicella Vaccine and...” NCT06855160
43

“All participants will be randomized to receive either one dose each of DTap-IPV + Measles, Mumps, and Rubella Virus Vaccine Live (M-M-R®II) + VARIVAX® or one dose each of...” NCT01346293

“GSK Biologicals' Inactivated Hepatitis A Vaccine (Havrix™) Co-administered With Merck & Company, Inc. Measles-Mumps-Rubella Vaccine (M-M-RII) & Merck & Co Varicella Vaccine...” NCT00197015

“varicella vaccine (VARIVAX™) passage extension 34 (PE34) process administered concomitantly with measles, mumps, and rubella vaccine (M-M-R™ II).” PMID 32429738 May 2020

Varivax is a vaccine against varicella zoster virus (VZV), the virus that causes chickenpox (varicella) and shingles (zoster).” NCT00000837

“compared to the licensed varicella vaccine, Varivax (VV), as a first dose for children aged 12 to 15 months in the US.” NCT05084508

“M-M-R® II (measles, mumps, and rubella vaccine) and VARIVAX® (varicella vaccine) at 12 months of age” NCT03673462

“Live, attenuated varicella vaccine, VarivaxNCT00505063

NCT03620162

NCT00258726

NCT00005009

NCT00861744

NCT03893448

NCT00839917

NCT03239873

NCT03843632

NCT01439360

NCT00871117

NCT03621670

NCT07054099

NCT01702428

NCT05422508

NCT02367638

NCT00975507

NCT00432523

NCT03114943

NCT03114982

NCT06824194

NCT00985166

NCT06824181

NCT00985153

NCT00289783

NCT03121638

NCT00345683

NCT01681992

NCT06975878

NCT06736041

NCT04016714

NCT00984295

NCT00432731

NCT00197015

NCT00134719

NCT07415252

NCT06314724

Known as Herpes Zoster (HZ) Vaccine ClinicalTrials.gov intervention name — accepted as the source's own label NCT02538341
Known as HPV vaccine, Merck ClinicalTrials.gov intervention name — accepted as the source's own label NCT04774887
Known as Live, attenuated varicella vaccine, Varivax Live, attenuated varicella vaccine, VarivaxNCT00505063
Known as Oka/Merck VZV vaccine “investigational live attenuated Oka/Merck VZV vaccine ("zoster vaccine")” PMID 15930418 Jun 2005
Known as ProVarivax “subjects received Prevenar 13® or Havrix® Junior and possibly a varicella vaccine (Varilrix® or Varivax/ProVarivax ®).” NCT01439360
Known as Shingles Vaccine “Bacterial or Viral infection treatment may include: Doxycycline, Minocycline, Nitazoxanide, Hydroxychloroquine, Rifampin, Dapsone, Azithromycin, Tetracycline, Benzathine...” NCT05894954
Known as Varicella vaccine live ClinicalTrials.gov intervention name — accepted as the source's own label NCT05794230
Known as Varicella Virus Vaccine ClinicalTrials.gov intervention name — accepted as the source's own label NCT03673462
1

NCT06397768

Known as Varicella Virus Vaccine Live “VARIVAX™ administered by SC injection as 0.5 mL Varicella Virus Vaccine Live in sterile suspension” NCT03843632
5

NCT03691610

NCT01049035

NCT00000837

NCT04398706

NCT00001125

Known as Varicella Virus Vaccine Live (1999 Process) (Oka/Merck) ClinicalTrials.gov intervention name — accepted as the source's own label NCT00822237
Known as Varicella Virus Vaccine Live (2007 Process) (Oka/Merck) ClinicalTrials.gov intervention name — accepted as the source's own label NCT00822237
Known as Varicella Virus Vaccine Live [Oka/Merck] “Participants aged 12 months-12 years were administered 1 dose of VARIVAX™ 0.5 mL (Varicella Virus Vaccine Live [Oka/Merck]) and adolescents aged 13-17 years were administered 2...” PMID 34702124 Oct 2021
Known as Varicella Zoster Virus Vaccine Varicella Zoster Virus Vaccine (Zostavax)” NCT01262300
1

NCT03314103

Known as Varicella Zoster Virus Vaccine Live (Oka/Merck) “Evaluation of the Safety and Tolerability of a Higher Potency Dose of Varicella Zoster Virus Vaccine Live (Oka/Merck)Among Adults 50 Years of Age or Older” NCT00092417
Known as Varicella-zoster vaccine ClinicalTrials.gov intervention name — accepted as the source's own label NCT00007501
1

NCT02408159

Known as VZV vaccine ClinicalTrials.gov intervention name — accepted as the source's own label NCT01953900
Known as ZOSTAVAX ZOSTAVAX® (Zoster Vaccine Live) is a live attenuated vaccine provided as a single-dose, sterile, lyophilized, preservative-free frozen formulation.” NCT01137669
33

“Safety and Immunogenicity of Zoster Vaccine (ZOSTAVAX™) Made With an Alternative Manufacturing Process” NCT01505647

“Varicella Zoster Vaccine (Zostavax)” NCT03604406

“zoster vaccine live (ZOSTAVAX™)” NCT00322231

ZOSTAVAX™” NCT00535730

NCT02960399

NCT02519855

NCT03120364

NCT00561080

NCT00940940

NCT00851786

NCT00231816

NCT02329457

NCT02114333

NCT01213810

NCT01331161

NCT01385566

NCT03116594

NCT01911065

NCT02958345

NCT03192319

NCT02444936

NCT01474720

NCT01506661

NCT01262300

NCT00886613

NCT03121638

NCT01391546

NCT02704572

NCT01573182

NCT03016884

NCT00681031

NCT00535730

NCT02477150

Known as ZOSTAVAX (Zoster Vaccine Live) “ZOSTAVAX® (Zoster Vaccine Live)” NCT03016884
Known as zoster vaccine “One dose of zoster vaccine (ZV) has demonstrated substantial protection against HZ” PMID 22154769 Dec 2011
2

“investigational live attenuated Oka/Merck VZV vaccine ("zoster vaccine")” PMID 15930418 Jun 2005

NCT04072497

Known as Zoster Vaccine Live “ZOSTAVAX® (Zoster Vaccine Live) is a live attenuated vaccine provided as a single-dose, sterile, lyophilized, preservative-free frozen formulation.” NCT01137669
15

“ZOSTAVAX™ (Zoster Vaccine Live) Full Dose Subcutaneous” NCT01385566

“ZOSTAVAX® (Zoster Vaccine Live)” NCT00851786

“Zostavax (Zoster Vaccine Live)” NCT02538341

Zoster vaccine liveNCT00561080

NCT02590068

NCT06851832

NCT01245751

NCT00550745

NCT00322231

NCT01505647

NCT00546819

NCT01556451

NCT00534248

NCT01527370

NCT02624375

Known as Zoster Vaccine, Live (AMP) ClinicalTrials.gov intervention name — accepted as the source's own label NCT01505647
Known as Zoster Vaccine, Live, (Oka-Merck) Zoster Vaccine, Live, (Oka-Merck), ZOSTAVAX™” NCT00535730
3

NCT00109122

NCT00444860

NCT00130793

Known as ZVL “Protection against zoster conferred by zoster vaccine live (ZVL; Zostavax) wanes over time.” PMID 30165651 Jan 2019
1

“live attenuated zoster vaccine (ZVL)” PMID 34570596 Sep 2021

Action Activate “Vaccination with an attenuated form of the VZV activates specific T-cell production avoiding viral reactivation.” PMID 37781954 Oct 2023