Drugs / Triplex
last change Jun 2026 re-read 9 days ago

Triplex

Vaccine

Developed for
cytomegalovirus infection
Investigated by
City of Hope Medical Center · National Cancer Institute (NCI) · Diavax Biosciences

Trials 2

201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT04060277 Nov 2019 → Jun 2023 overdue Hodgkins lymphoma, acute myeloid leukemia, chronic lymphocytic leukemia/small lymphocytic lymphoma, leukemia, myeloid, accelerated-phase +3 City of Hope Medical Center Active not recruiting No outcome recorded
Phase 2 NCT02506933 Dec 2015 → Jan 2018 overdue B-cell chronic lymphocytic leukemia, Hodgkins lymphoma, acute myeloid leukemia, cytomegalovirus infection +5 City of Hope Medical Center Active not recruiting Missed primary

Evidence & citations 3 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as Triplex “The Triplex vaccine is made up of 3 small pieces of CMV deoxyribonucleic acid (DNA) (the chemical form of genes) placed into a weakened virus called modified vaccinia Ankara (MVA)” NCT04060277 ↗
1

“Triplex is a recombinant attenuated poxvirus (modified vaccinia Ankara) expressing immunodominant CMV antigens.” PMID 32040960 ↗ Feb 2020

Modality Vaccine “Triplex vaccine” NCT04060277 ↗
Route Intramuscular “Intramuscular injections of Triplex or placebo were given on days 28 and 56 after HCT.” PMID 32040960 ↗ Feb 2020