Drugs / monomethyl fumarate
monomethyl fumarate
also known as
Bafiertam · Bafiertam (monomethyl fumarate) · Fumarate de monomethyle · Fumarato de monometilo · Fumaric acid monomethyl ester · MMF · NSC-523835
Small molecule targets KEAP1 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | BAFIERTAM | — | 2020-04-28 | fda.gov ↗ |
Trials 3
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 12 trials · 1 met primary | ||||||
| Phase 1 | NCT04022473 | Jul → Oct 2019 | multiple sclerosis | Banner Life Sciences LLC | Completed | No outcome recorded |
| Phase 1 | NCT04570670 | Jan → Feb 2017 | relapsing-remitting multiple sclerosis | Banner Life Sciences LLC | Completed | Met primary |
| Phase 41 trial | ||||||
| Phase 4 | NCT03535298 | Jan 2019 → Jul 2027 expected | relapsing-remitting multiple sclerosis | The Cleveland Clinic | Active not recruiting | No outcome recorded |
Press releases naming this drug 1 release
| Date | Issuer | Release |
|---|---|---|
| 2025-03-31 | Cycle Pharmaceuticals Ltd. | Cycle Vita™ expands patient support in Multiple Sclerosis (MS) to include BAFIERTAM<sup>®</sup> (monomethyl fumarate) delayed-release capsules cyclepharma.com ↗ |
Evidence & citations 12 cited values
Every value below carries the sentence it was read from. 4 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | monomethyl fumarate | “Bafiertam (monomethyl fumarate)” NCT03535298 ↗ |
| Known as | Bafiertam | ClinicalTrials.gov intervention name — accepted as the source's own label NCT04022473 ↗ |
| Known as | Bafiertam (monomethyl fumarate) | “Bafiertam (monomethyl fumarate)” NCT03535298 ↗ |
| Known as | Fumarate de monomethyle | ChEMBL registry synonym — accepted as the source's own label CHEMBL589586 ↗ |
| Known as | Fumarato de monometilo | ChEMBL registry synonym — accepted as the source's own label CHEMBL589586 ↗ |
| Known as | Fumaric acid monomethyl ester | ChEMBL registry synonym — accepted as the source's own label CHEMBL589586 ↗ |
| Known as | MMF | “The primary objective of this study was to assess the bioequivalence of the test product (Bafiertam; BLS-11; monomethyl fumarate) 190 mg versus Tecfidera® (dimethyl fumarate)...” NCT04570670 ↗ |
| Known as | NSC-523835 | ChEMBL registry synonym — accepted as the source's own label CHEMBL589586 ↗ |
| Action | Inhibit | “Kelch-like ECH-associated protein 1 inhibitor” CHEMBL589586 ↗ |
| Modality | Small molecule | — CHEMBL589586 ↗ |
| Route | Oral | “Secondary objective of this study is to compare the safety and tolerability of Bafiertam™ and Tecfidera® when administered orally following bioequivalent dose regimens in...” NCT04022473 ↗ |
| Target | KEAP1 | “Kelch-like ECH-associated protein 1 inhibitor” CHEMBL589586 ↗ |