Drugs / V591
Trials 2
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial · 1 missed | ||||||
| Phase 1 | NCT04497298 | Aug 2020 → May 2021 | COVID-19 | Institut Pasteur | Completed | Missed primary |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT04498247 | Aug 2020 → Mar 2021 | COVID-19 | Merck Sharp & Dohme LLC | Terminated | No outcome recorded |
News releases announcing trial results or a regulatory action · 1
| Date | Issuer | Release |
|---|---|---|
| 2021-01-25 | Merck Sharp & Dohme LLC | Results Merck Discontinues Development of SARS-CoV-2/COVID-19 Vaccine Candidates; Continues Development of Two Investigational Therapeutic Candidates merck.com ↗
In these studies, both V590 and V591 were generally well tolerated, but the immune responses were inferior to those seen following natural infection and those reported for other SARS-CoV-2/COVID-19 vaccines. |
All press releases naming this drug 1 release
| Date | Issuer | Release |
|---|---|---|
| 2021-01-25 | Merck Sharp & Dohme LLC | Merck Discontinues Development of SARS-CoV-2/COVID-19 Vaccine Candidates; Continues Development of Two Investigational Therapeutic Candidates merck.com ↗ |
Evidence & citations 4 cited values
Every value below carries the sentence it was read from. 3 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | V-591 | “V591 (TMV-083) is a live recombinant measles vector-based vaccine candidate expressing a pre-fusion stabilized SARS-CoV-2 spike protein.” PMID 35045362 ↗ Jan 2022 |
| Known as | TMV-083 | “V591 (TMV-083) is a live recombinant measles vector-based vaccine candidate expressing a pre-fusion stabilized SARS-CoV-2 spike protein.” PMID 35045362 ↗ Jan 2022 |
| Modality | Vaccine | “live recombinant measles vector-based vaccine candidate” PMID 35045362 ↗ Jan 2022 |
| Route | Intramuscular | “Volunteers will receive two administrations of the low dose COVID-19 vaccine candidate by intramuscular (i.m.) injection on day 0 and 28” NCT04497298 ↗ |