Drugs / SLC-391
last change Dec 2025 re-read 3 minutes ago

SLC-391

also known as SLC-0211

Small molecule targets AXL via inhibition

Developed for
cancer · non-small cell lung carcinoma
Investigated by
SignalChem Lifesciences Corporation · Merck Sharp & Dohme LLC · Syneos Health

Trials 3

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT05278845 Feb → Jun 2022 — SignalChem Lifesciences Corporation Completed No outcome recorded
Phase 1 NCT03990454 Sep 2019 → Jun 2023 cancer SignalChem Lifesciences Corporation Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT05860296 May 2023 → Dec 2025 non-small cell lung carcinoma SignalChem Lifesciences Corporation Terminated No outcome recorded Stop: Enrollment

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as SLC-391 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05278845 ↗
2

NCT05860296 ↗

NCT03990454 ↗

Known as SLC-0211 ChEMBL registry synonym — accepted as the source's own label CHEMBL5095196 ↗
Action Inhibit “SLC-391 is an AXL inhibitor” NCT03990454 ↗
Modality Small molecule “SLC-391 is a novel, potent and specific small molecule inhibitor of receptor tyrosine kinase AXL” NCT05860296 ↗
Route Oral “SLC-391 administered orally” NCT03990454 ↗
Target AXL “SLC-391 is an AXL inhibitor” NCT03990454 ↗