Drugs / ENDOTHELIN
ENDOTHELIN
Trials 4
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 01 trial | ||||||
| Phase 0 | NCT05653973 | Jan 2023 → Mar 2027 expected | preeclampsia | Anna Stanhewicz, PhD | Recruiting | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT00406731 | Jan 2008 → Nov 2014 | — | Medical University of Vienna | Withdrawn | No outcome recorded |
| Phase not applicable2 trials | ||||||
| — | NCT02906085 | Oct 2016 → May 2018 | migraine with aura | Glostrup University Hospital, Copenhagen | Unknown | No outcome recorded |
| — | NCT00745693 | Mar → May 2008 | coronary artery disorder | University of Edinburgh | Completed | No outcome recorded |
Press releases naming this drug 2 releases
| Date | Issuer | Release |
|---|---|---|
| 2025-08-28 | Idorsia Pharmaceuticals Ltd. | Idorsia’s TRYVIO – First FDA-approved therapy to target the endothelin pathway for systemic hypertension idorsia.com ↗ |
| 2024-03-20 | Idorsia Pharmaceuticals Ltd. | US FDA approves Idorsia’s once-daily TRYVIO (aprocitentan) – the first and only endothelin receptor antagonist for the treatment of high blood pressure not adequately controlled in combination with other antihypertensives idorsia.com ↗ |
Evidence & citations 12 cited values
Every value below carries the sentence it was read from. 5 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | ENDOTHELIN | ChEMBL registry synonym — accepted as the source's own label CHEMBL437472 ↗ |
| Known as | American Peptides - 88-1-10 (ET-1) | “American Peptides - 88-1-10 (ET-1)” NCT00745693 ↗ |
| Known as | Endothelin (porcine) | ChEMBL registry synonym — accepted as the source's own label CHEMBL437472 ↗ |
| Known as | Endothelin 1 (human) | ChEMBL registry synonym — accepted as the source's own label CHEMBL437472 ↗ |
| Known as | Endothelin 1 (pig) | ChEMBL registry synonym — accepted as the source's own label CHEMBL437472 ↗ |
| Known as | Endothelin 1 (rana ridibunda) | ChEMBL registry synonym — accepted as the source's own label CHEMBL437472 ↗ |
| Known as | Endothelin 1 (rat) | ChEMBL registry synonym — accepted as the source's own label CHEMBL437472 ↗ |
| Known as | Endothelin-1 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT02906085 ↗ |
| Known as | ET-1 | “Endothelin-1 (ET-1)” NCT00406731 ↗ |
| Known as | Human endothelin | ChEMBL registry synonym — accepted as the source's own label CHEMBL437472 ↗ |
| Modality | Peptide | “Peptide Endothelin-1” NCT02906085 ↗ |
| Route | Intravenous | “5 ng/kg/min intravenous infusion over 17 minutes” NCT00406731 ↗ |