Drugs / SAR425899
last change Aug 2021 re-read 2 minutes ago

SAR425899

Peptide targets GCGR via activation

Developed for
type 2 diabetes mellitus · metabolic dysfunction-associated steatohepatitis
Investigated by
Sanofi · Antaros Medical

Trials 6 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT03376802 Apr → Dec 2018 type 2 diabetes mellitus Sanofi Completed No outcome recorded
Phase 1 NCT03414736 Jan → Oct 2018 type 2 diabetes mellitus Sanofi Completed No outcome recorded
Phase 1 NCT03350191 Dec 2017 → Jun 2018 type 2 diabetes mellitus Sanofi Completed No outcome recorded
Phase 1 NCT02411825 Mar 2015 → Jan 2016 type 2 diabetes mellitus Sanofi Completed No outcome recorded
Phase 22 trials
Phase 2 NCT03437720 May 2019 → Aug 2021 metabolic dysfunction-associated steatohepatitis, type 2 diabetes mellitus Sanofi Withdrawn No outcome recorded
Phase 2 NCT02973321 Dec 2016 → Dec 2017 type 2 diabetes mellitus Sanofi Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as SAR425899 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02973321
5

NCT03350191

NCT03414736

NCT03437720

NCT02411825

NCT03376802

Action Activate “active as an agonist at both the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCR)” PMID 30091218 Sep 2018
1

“Glucagon receptor agonist” CHEMBL3545269

Modality Peptide “SAR425899, a novel polypeptide, active as an agonist” PMID 30091218 Sep 2018
Route Subcutaneous “Route of administration: subcutaneousNCT02411825
Target GCGR “Glucagon receptor agonist” CHEMBL3545269