Drugs / LONDAMOCITINIB
last change Oct 2025 re-read 3 minutes ago

LONDAMOCITINIB

also known as AZD4604

Small molecule targets JAK1 via inhibition

Developed for
asthma
Investigated by
AstraZeneca · Parexel · Quotient Sciences

Trials 6

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT06732882 Feb → May 2025 asthma AstraZeneca Completed No outcome recorded
Phase 1 NCT06519968 Jul → Dec 2024 — AstraZeneca Completed No outcome recorded
Phase 1 NCT06157255 Feb → May 2024 asthma AstraZeneca Completed No outcome recorded
Phase 1 NCT04769869 Jul 2022 → Jan 2023 asthma AstraZeneca Completed No outcome recorded
Phase 22 trials
Phase 2 NCT06435273 Aug 2024 → Oct 2025 asthma AstraZeneca Completed No outcome recorded
Phase 2 NCT06020014 Nov 2023 → Oct 2025 asthma AstraZeneca Completed No outcome recorded

News releases announcing trial results or a regulatory action · 1

DateIssuerRelease
2024-05-01 AstraZeneca Results AstraZeneca unveils latest research across key respiratory and immune-mediated diseases at ATS 2024 showcasing strength of its broad pipeline and portfolio astrazeneca.com ↗
Findings from a preclinical study of AZD4604, an inhaled, small molecule selective Janus Kinase 1 (JAK1) inhibitor in development for the treatment of moderate-to-severe asthma.

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as LONDAMOCITINIB ChEMBL registry synonym — accepted as the source's own label CHEMBL4447181 ↗
Known as AZD4604 ClinicalTrials.gov intervention name — accepted as the source's own label NCT06157255 ↗
5

NCT06020014 ↗

NCT04769869 ↗

NCT06732882 ↗

NCT06519968 ↗

NCT06435273 ↗

Action Inhibit “Janus kinase 1 (JAK1) inhibitor” NCT06435273 ↗
Modality Small molecule — CHEMBL4447181 ↗
Route Inhaled “inhaled AZD4604” NCT04769869 ↗
Target JAK1 “Janus kinase 1 (JAK1) inhibitor” NCT06435273 ↗