Drugs / Tecarfarin
Tecarfarin
also known as
ATI-5923 · 60 TIS 99 · ATI-5923 SODIUM SALT · TECARFARIN SODIUM · Tecarfarina · Tecarfarine
Small molecule targets VKORC1 via inhibition
Trials 5 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 12 trials | ||||||
| Phase 1 | NCT04627116 | Apr → Dec 2020 | — | Lee's Pharmaceutical Limited | Unknown | No outcome recorded |
| Phase 1 | NCT03652779 | Jun 2018 → Oct 2019 | — | Lee's Pharmaceutical Limited | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT00431782 | Dec 2006 → Oct 2007 | atrial fibrillation | ARYx Therapeutics | Completed | No outcome recorded |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT00691470 | May 2008 → Jun 2009 | atrial fibrillation, atrial flutter, cardiomyopathy, myocardial infarction +1 | ARYx Therapeutics | Unknown | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT02522221 | Jun 2018 → Mar 2019 | thrombotic disease | Espero Biopharma | Unknown | No outcome recorded |
Evidence & citations 11 cited values
Every value below carries the sentence it was read from. 8 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | tecarfarin | “The first evaluation of a novel vitamin K antagonist, tecarfarin (ATI-5923), in patients with atrial fibrillation.” PMID 19738136 ↗ Sep 2009 |
| Known as | 60 TIS 99 | ChEMBL registry synonym — accepted as the source's own label CHEMBL2105664 ↗ |
| Known as | ATI-5923 | “An Open-label, Phase 1, Sequential Cohort, Single-Dose Escalation Study to Assess the Safety and Tolerability of Tecarfarin (ATI-5923) in Healthy Chinese Volunteers” NCT03652779 ↗3“BACKGROUND: Tecarfarin (ATI-5923), a structural analog of warfarin, was designed to provide more uniform and stable anticoagulation.” PMID 36622539 ↗ Jan 2023 |
| Known as | ATI-5923 SODIUM SALT | ChEMBL registry synonym — accepted as the source's own label CHEMBL2105664 ↗ |
| Known as | TECARFARIN SODIUM | ChEMBL registry synonym — accepted as the source's own label CHEMBL2105664 ↗ |
| Known as | Tecarfarina | ChEMBL registry synonym — accepted as the source's own label CHEMBL2105664 ↗ |
| Known as | Tecarfarine | ChEMBL registry synonym — accepted as the source's own label CHEMBL2105664 ↗ |
| Action | Inhibit | “ATI-5923 is a selective, non-competitive inhibitor of vitamin K epoxide reductase.” NCT00431782 ↗1“Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor” CHEMBL2105664 ↗ |
| Modality | Small molecule | — CHEMBL2105664 ↗ |
| Route | Oral | “ATI-5923 is a structural analog of warfarin that is being developed as an oral anticoagulant.” NCT00431782 ↗ |
| Target | VKORC1 | “Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor” CHEMBL2105664 ↗ |