Drugs / Trilostane
Trilostane
also known as
Brand name Modrenal · Desopan · Modrastane · Modrenal · NSC-758904 · Trilocur · Trilorale · Trilostano · +1 more
Small molecule targets HSD3B2 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | MODRASTANE | — | 1984-12-31 | fda.gov ↗ |
Trials 1 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 2 | NCT00181597 | Mar 2004 → Jan 2006 | prostate adenocarcinoma | Genzyme, a Sanofi Company | Completed | No outcome recorded |
Also used as a comparator or background therapy in 1 trial
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 2 | NCT01615211 Comparator | May 2012 → Oct 2013 | — | Kristina Gemzell Danielsson | Terminated | No outcome recorded |
Evidence & citations 14 cited values
Every value below carries the sentence it was read from. 3 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Trilostane | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01615211 ↗ |
| Known as | Brand name Modrenal | “Brand name Modrenal” NCT01615211 ↗ |
| Known as | Desopan | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200907 ↗ |
| Known as | Modrastane | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200907 ↗ |
| Known as | Modrenal | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200907 ↗ |
| Known as | NSC-758904 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200907 ↗ |
| Known as | Trilocur | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200907 ↗ |
| Known as | Trilorale | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200907 ↗ |
| Known as | Trilostano | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200907 ↗ |
| Known as | WIN 24,540 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200907 ↗ |
| Action | Inhibit | “3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II inhibitor” CHEMBL1200907 ↗ |
| Modality | Small molecule | — CHEMBL1200907 ↗ |
| Route | Oral | “Taken orally once a day for three days then twice daily thereafter.” NCT00181597 ↗ |
| Target | HSD3B2 | “3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II inhibitor” CHEMBL1200907 ↗ |