Drugs / Xaliproden
last change Nov 2009 re-read 3 minutes ago

Xaliproden

Small molecule targets HTR1A via activation

Developed for
Alzheimer disease · colorectal carcinoma · metastatic neoplasm
Investigated by
Sanofi

Trials 5

20022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 3 NCT00603577 Jan 2008 → Nov 2009 colorectal neoplasm Sanofi Terminated No outcome recorded
Phase 3 NCT00305188 Dec 2005 → Oct 2009 colorectal carcinoma, metastatic neoplasm Sanofi Completed No outcome recorded
Phase 3 NCT00104013 Nov 2003 → Nov 2007 Alzheimer disease Sanofi Completed No outcome recorded
Phase 3 NCT00103649 Nov 2003 → Oct 2007 Alzheimer disease Sanofi Completed No outcome recorded
Phase 3 NCT00272051 Jul 2002 → May 2004 colorectal carcinoma, metastatic neoplasm Sanofi Completed No outcome recorded

Evidence & citations 10 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as xaliproden “Purpose of the trial is to evaluate the efficacy of Xaliproden in reducing the neurotoxicity of the Oxaliplatin and 5-FU/LV chemotherapy” NCT00272051 ↗
4

NCT00104013 ↗

NCT00305188 ↗

NCT00603577 ↗

NCT00103649 ↗

Known as SR 57746 ChEMBL registry synonym — accepted as the source's own label CHEMBL1512580 ↗
Known as SR57746A “xaliproden (SR57746A)” NCT00104013 ↗
2

“Xaliproden (SR57746A)” NCT00305188 ↗

“xaliproden (SR57746A)” NCT00103649 ↗

Known as xaliproden hydrochloride “To assess the effect of xaliproden hydrochloride (xaliproden) 1 mg per oral daily on the rate of complete resolution of peripheral sensory neuropathy (PSN) at 6 months,...” NCT00603577 ↗
Known as Xaliprodene ChEMBL registry synonym — accepted as the source's own label CHEMBL1512580 ↗
Known as Xaliprodeno ChEMBL registry synonym — accepted as the source's own label CHEMBL1512580 ↗
Action Activate “Serotonin 1a (5-HT1a) receptor agonist” CHEMBL1512580 ↗
Modality Small molecule — CHEMBL1512580 ↗
Route Oral “The patients participating in this study will take orally once daily xaliproden or placebo (inactive substance pill).” NCT00103649 ↗
Target HTR1A “Serotonin 1a (5-HT1a) receptor agonist” CHEMBL1512580 ↗