Drugs / NA-1
last change Apr 2020 re-read 3 minutes ago

NA-1

also known as Tat-NR2B9c

Peptide

Developed for
brain aneurysm · stroke disorder · subarachnoid hemorrhage
Investigated by
NoNO Inc. · Arbor Vita Corporation

Trials 2

2009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT02056574 Nov 2015 → Nov 2019 brain aneurysm, subarachnoid hemorrhage NoNO Inc. Withdrawn No outcome recorded
Phase 2 NCT00728182 Aug 2008 → Apr 2011 stroke disorder NoNO Inc. Completed Missed primary

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as NA-1 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00728182 ↗
1

NCT02056574 ↗

Known as Tat-NR2B9c “Neuroprotection with NA-1 (Tat-NR2B9c), an inhibitor of postsynaptic density-95 protein, has been shown in a primate model of stroke.” PMID 23051991 ↗ Oct 2012
Action Inhibit “an inhibitor of postsynaptic density-95 protein” PMID 23051991 ↗ Oct 2012
Modality Peptide “20 amino acid peptide that consists of a 9 amino acid domain that inhibits PSD-95 and a 11 amino acid domain than enables the peptide to cross the blood-brain barrier.” NCT00728182 ↗
Route Intravenous “intravenous infusion” NCT00728182 ↗