Drugs / HER-2/neu intracellular domain protein
last change Sep 2007 re-read 2 minutes ago

HER-2/neu intracellular domain protein

Protein / enzyme biologic targets ERBB2 via depletion

Developed for
breast cancer · gastric cancer · ovarian cancer
Investigated by
Duke University · National Cancer Institute (NCI)

Trials 1 · a red edge is where a trial was stopped

2000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
NCT00005956 Feb 2000 → Aug 2001 breast cancer, gastric cancer, ovarian cancer Duke University Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as HER-2/neu intracellular domain protein ClinicalTrials.gov intervention name — accepted as the source's own label NCT00005956
Action Deplete “A person's white blood cells mixed with tumor proteins may make the body build an immune response to kill tumor cells” NCT00005956
Modality Protein / enzyme biologic “vaccination with HER2 ICD protein-containing DC” PMID 17822557 Sep 2007
Route Subcutaneous “The pulsed DC are administered subcutaneously (SQ) and intradermally” NCT00005956
Target ERBB2 “cancer vaccines to stimulate HER2 intracellular domain (ICD)-specific T cell and antibody responses” PMID 17822557 Sep 2007