Drugs / HER-2/neu intracellular domain protein
last change Sep 2007 re-read 9 days ago

HER-2/neu intracellular domain protein

Protein / enzyme biologic targets ERBB2 via depletion

Developed for
breast cancer · gastric cancer · ovarian cancer
Investigated by
Duke University · National Cancer Institute (NCI)

Trials 1

2000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
— NCT00005956 Feb 2000 → Aug 2001 breast cancer, gastric cancer, ovarian cancer Duke University Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as HER-2/neu intracellular domain protein ClinicalTrials.gov intervention name — accepted as the source's own label NCT00005956 ↗
Action Deplete “A person's white blood cells mixed with tumor proteins may make the body build an immune response to kill tumor cells” NCT00005956 ↗
Modality Protein / enzyme biologic “vaccination with HER2 ICD protein-containing DC” PMID 17822557 ↗ Sep 2007
Route Subcutaneous “The pulsed DC are administered subcutaneously (SQ) and intradermally” NCT00005956 ↗
Target ERBB2 “cancer vaccines to stimulate HER2 intracellular domain (ICD)-specific T cell and antibody responses” PMID 17822557 ↗ Sep 2007