Drugs / AMG 650
last change Apr 2026 re-read 3 minutes ago

AMG 650

also known as Sovilnesib

Small molecule targets KIF18A via inhibition

Developed for
fallopian tube cancer · neoplasm · ovarian serous adenocarcinoma · primary peritoneal carcinoma
Investigated by
Volastra Therapeutics, Inc. · Amgen

Trials 2

2020202120222023202420252026
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT06084416 Apr 2024 → Mar 2026 overdue fallopian tube cancer, ovarian serous adenocarcinoma, primary peritoneal carcinoma Volastra Therapeutics, Inc. Active not recruiting No outcome recorded
Phase 1 NCT04293094 Mar 2020 → Oct 2022 neoplasm Volastra Therapeutics, Inc. Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as AMG 650 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04293094 ↗
Known as Sovilnesib ClinicalTrials.gov intervention name — accepted as the source's own label NCT06084416 ↗
Action Inhibit “KIF18A Inhibitor” NCT06084416 ↗
Modality Small molecule — CHEMBL5084301 ↗
Route Oral “AMG 650 administered orally as a tablet.” NCT04293094 ↗
Target KIF18A “KIF18A Inhibitor” NCT06084416 ↗