Drugs / CYD Dengue Vaccine
last change Mar 2026 re-read 2 minutes ago

CYD Dengue Vaccine

Vaccine

Developed for
Dengue hemorrhagic fever
Investigated by
Sanofi Pasteur, a Sanofi Company · Sanofi · United States Department of Defense

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Withdrawn EU (EMA) Dengvaxia 2025-10-21 europa.eu
Approved EU (EMA) Dengvaxia 2018-12-12 europa.eu

Trials 12 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 28 trials
Phase 2 NCT02741128 Nov 2019 → Jan 2023 Dengue hemorrhagic fever, HIV infectious disease Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 2 NCT02628444 May 2016 → Apr 2020 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 2 NCT02623725 Apr → Nov 2016 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 2 NCT01943825 Nov 2013 → Nov 2015 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 2 NCT01064141 Jan 2010 → Sep 2012 Dengue hemorrhagic fever Sanofi Completed No outcome recorded
Phase 2 NCT00880893 Apr 2009 → Oct 2014 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 2 NCT00875524 Mar 2009 → Aug 2014 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 2 NCT00842530 Feb 2009 → Sep 2013 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 34 trials
Phase 3 NCT02992418 Dec 2016 → Dec 2019 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Terminated No outcome recorded
Phase 3 NCT02993757 Dec 2016 → May 2019 Dengue hemorrhagic fever, human papilloma virus infection Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 3 NCT02979535 Nov 2016 → Mar 2019 Dengue hemorrhagic fever, human papilloma virus infection Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 3 NCT01411241 Jul 2011 → Feb 2014 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 0 NCT05476757 Background Aug 2022 → Jan 2023 dengue disease Mahidol University Unknown No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 19 sources stand behind the page.

FieldValueCited text
Known as CYD Dengue Vaccine “The aim of the study was to investigate the immunogenicity and safety of CYD dengue vaccine and Tetanus Toxoid (T), Reduced Diphtheria Toxoid (D) and Acellular Pertussis...” NCT02992418
13

“The purpose of this study is to investigate the potential for co-administration of the first dose of CYD Dengue vaccine with childhood vaccination.” NCT01064141

CYD Dengue VaccineNCT01064141

CYD Dengue VaccineNCT01411241

NCT02628444

NCT02741128

NCT00875524

NCT02979535

NCT00880893

NCT01943825

NCT02992418

NCT02623725

NCT00842530

NCT02993757

Known as CYD-TDV “BACKGROUND: Incorporating dengue vaccination into existing childhood vaccination programs could increase vaccine coverage. This study assessed the safety and immunogenicity of...” PMID 34117198 Sep 2021
5

“We assessed the immunogenicity and safety of a quadrivalent human papillomavirus (HPV) vaccine administered concomitantly or sequentially with a tetravalent dengue vaccine...” PMID 34250977 Aug 2021

“Three doses of the licensed tetravalent dengue vaccine CYD-TDV (Dengvaxia, Sanofi Pasteur, Lyon France) are immunogenic and effective against symptomatic dengue” PMID 33212067 Nov 2020

“The tetravalent dengue vaccine (CYD-TDV, Dengvaxia, Sanofi Pasteur) demonstrated efficacy in 2 previous phase III trials conducted in endemic countries.” PMID 30986790 May 2019

“The recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV) is recommended for dengue seropositive individuals” PMID 33992441 May 2021

CYD-TDV, a live, attenuated, tetravalent dengue vaccine” PMID 33822015 Sep 2021

Known as Dengvaxia “Three doses of the licensed tetravalent dengue vaccine CYD-TDV (Dengvaxia, Sanofi Pasteur, Lyon France) are immunogenic and effective against symptomatic dengue” PMID 33212067 Nov 2020
2

“The tetravalent dengue vaccine (CYD-TDV, Dengvaxia, Sanofi Pasteur) demonstrated efficacy in 2 previous phase III trials conducted in endemic countries.” PMID 30986790 May 2019

“the participants will be vaccinated with Dengvaxia® until completion of 3 doses with 6-month interval between each dose.” NCT05476757

Known as Sanofi Pasteur's CYD Dengue Vaccine Sanofi Pasteur's CYD Dengue VaccineNCT00880893
Modality Vaccine “CYD-TDV, a live, attenuated, tetravalent dengue vaccinePMID 33822015 Sep 2021
Route Subcutaneous “0.5 mL, SubcutaneousNCT00842530