Drugs / Levosulpiride
Levosulpiride
also known as
L-sulpiride · Lesuride · Levobren · Levopraid · Levopride · Levosulpirida · S-(-)-sulpiride · Sulpiride l-form
Small molecule targets DRD2, HTR4 via inhibition / activation
Trials 3
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT02481583 | Mar → May 2013 | dyspepsia | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT03161652 | May 2017 → Dec 2026 expected | diabetic macular edema | Carmen Clapp | Recruiting | No outcome recorded |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT00866645 | Feb 2009 → Jul 2010 | — | Shanghai Mental Health Center | Completed | No outcome recorded |
| Comparator or background therapy1 trial | ||||||
| — | NCT04697641 Comparator | Sep 2017 → May 2019 | Helicobacter pylori infectious disease, dyspepsia | Sir Ganga Ram Hospital | Completed | Missed primary |
Evidence & citations 15 cited values
Every value below carries the sentence it was read from. 5 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | levosulpiride | ClinicalTrials.gov intervention name — accepted as the source's own label NCT03161652 ↗ |
| Known as | L-sulpiride | ChEMBL registry synonym — accepted as the source's own label CHEMBL267044 ↗ |
| Known as | Lesuride | ChEMBL registry synonym — accepted as the source's own label CHEMBL267044 ↗ |
| Known as | Levobren | ChEMBL registry synonym — accepted as the source's own label CHEMBL267044 ↗ |
| Known as | Levopraid | ChEMBL registry synonym — accepted as the source's own label CHEMBL267044 ↗ |
| Known as | Levopride | ChEMBL registry synonym — accepted as the source's own label CHEMBL267044 ↗ |
| Known as | Levosulpirida | ChEMBL registry synonym — accepted as the source's own label CHEMBL267044 ↗ |
| Known as | S-(-)-sulpiride | ChEMBL registry synonym — accepted as the source's own label CHEMBL267044 ↗ |
| Known as | Sulpiride l-form | ChEMBL registry synonym — accepted as the source's own label CHEMBL267044 ↗ |
| Action | Activate | “Serotonin 4 (5-HT4) receptor agonist” CHEMBL267044 ↗ |
| Action | Inhibit | “The trial investigates a new specific therapy for DR and DME based on elevating the circulating levels of prolactin with the prokynetic, dopamine D2 receptor blocker, levosulpiride.” NCT03161652 ↗1“Dopamine D2 receptor antagonist” CHEMBL267044 ↗ |
| Modality | Small molecule | — CHEMBL267044 ↗ |
| Route | Intramuscular | “Intramuscular Levosulpiride” NCT00866645 ↗ |
| Target | DRD2 | “Dopamine D2 receptor antagonist” CHEMBL267044 ↗ |
| Target | HTR4 | “Serotonin 4 (5-HT4) receptor agonist” CHEMBL267044 ↗ |