Drugs / Hyperbaric oxygen
last change Aug 2025 re-read 3 minutes ago

Hyperbaric oxygen

also known as HBO2

Other / unclassified

Developed for
traumatic brain injury · traumatic encephalopathy · brain injury · carbon monoxide poisoning · diabetes mellitus · head and neck squamous cell carcinoma · infectious disease · myocardial disorder
+7 more · osteoradionecrosis · post-COVID-19 disorder · radiation-induced disorder · head and neck cancer · pyoderma gangrenosum · radiation cystitis · squamous cell carcinoma
Investigated by
Intermountain Health Care, Inc. · 59th Medical Wing · Barrett Cancer Center · CISSS de Chaudière-Appalaches · Dakota Medical Foundation · Dartmouth-Hitchcock Medical Center
+31 more · David Grant U.S. Air Force Medical Center · Deseret Foundation · EDC Scandinavia AB · Essentia Health · Gaylan Rockswold · Hull University Teaching Hospitals NHS Trust · JL Tol · Karolinska Institutet · Karolinska Trial Alliance · Karolinska University Hospital · Lindell Weaver · Mayo Clinic · Medical University of Graz · Memorial Hermann Hospital · National Baromedical Services · National Cancer Institute (NCI) · National Institute of Neurological Disorders and Stroke (NINDS) · North of England Medical & Hyperbaric Services · Per Rotbøll Nielsen · Prisma Health Richland Hospital · Radboud University Medical Center · Region Stockholm · State of North Dakota · Strategies to Innovate EmeRgENcy Care Clinical Trials Network · Swedish Heart Lung Foundation · The Swanson Foundation · The Swedish Research Council · U.S. Army Medical Research and Development Command · University of North Dakota · University of Rochester · William Jennings Bryan Dorn VA Medical Center

Trials 16

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT02563678 Apr 2015 → Dec 2023 infectious disease Intermountain Health Care, Inc. Unknown No outcome recorded
Phase 1/21 trial · 1 met primary
Phase 1/2 NCT00623142 Jan 2005 → Jan 2007 myocardial disorder Hull University Teaching Hospitals NHS Trust Completed Met primary
Phase 27 trials · 1 missed
Phase 2 NCT05173818 Jun 2022 → Aug 2025 traumatic encephalopathy Essentia Health Completed No outcome recorded
Phase 2 NCT04842448 Sep 2021 → Sep 2023 COVID-19, post-COVID-19 disorder Karolinska University Hospital Completed Missed primary
Phase 2 NCT03843671 Jul 2019 → Dec 2022 head and neck squamous cell carcinoma National Baromedical Services Unknown No outcome recorded
Phase 2 NCT03739502 Feb 2019 → Jun 2027 expected Hodgkins lymphoma, acute myeloid leukemia, myelodysplastic syndrome, non-Hodgkin lymphoma University of Rochester Active not recruiting No outcome recorded
Phase 2 NCT02407028 Jun 2018 → Oct 2028 expected traumatic brain injury Gaylan Rockswold Recruiting No outcome recorded
Phase 2 NCT01986205 Sep 2017 → May 2022 brain injury Lindell Weaver Completed No outcome recorded
Phase 2 NCT01611194 Sep 2012 → Jan 2015 traumatic brain injury, traumatic encephalopathy U.S. Army Medical Research and Development Command Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT00989820 Oct 2009 → May 2017 osteoradionecrosis Radboud University Medical Center Terminated No outcome recorded Stop: Enrollment
Phase 32 trials
Phase 3 NCT06526728 Oct 2024 → Sep 2027 expected — JL Tol Recruiting No outcome recorded
Phase 3 NCT02042339 Dec 2019 → Dec 2021 diabetes mellitus Medical University of Graz Unknown No outcome recorded
Phase 41 trial
Phase 4 NCT00465855 Jun 2007 → Sep 2016 carbon monoxide poisoning Intermountain Health Care, Inc. Completed No outcome recorded
Phase not applicable3 trials
— NCT02025686 Mar → Aug 2012 — Per Rotbøll Nielsen Completed No outcome recorded
— NCT01430325 Jul → Oct 2011 traumatic brain injury Intermountain Health Care, Inc. Completed No outcome recorded
— NCT00087815 Sep 2003 → Jun 2005 central nervous system neoplasm, cognitive disorder, radiation-induced disorder Barrett Cancer Center Unknown No outcome recorded
Comparator or background therapy3 trials
Phase 1 NCT00474825 Comparator Jul 2007 → Feb 2011 head and neck cancer, squamous cell carcinoma National Baromedical Services Completed No outcome recorded
Phase 2/3 NCT01659723 Comparator Aug 2012 → Aug 2018 radiation cystitis Göteborg University Completed No outcome recorded
Phase 3 NCT05343754 Comparator Jun 2022 → Jan 2024 pyoderma gangrenosum Erasmus Medical Center Terminated No outcome recorded Stop: Enrollment

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 20 sources stand behind the page.

FieldValueCited text
Known as Hyperbaric Oxygen ClinicalTrials.gov intervention name — accepted as the source's own label NCT00474825 ↗
18

NCT00087815 ↗

NCT01986205 ↗

NCT00623142 ↗

NCT00465855 ↗

NCT06526728 ↗

NCT01611194 ↗

NCT02042339 ↗

NCT05173818 ↗

NCT01659723 ↗

NCT03843671 ↗

Show 8 more sources

Known as HBO2 “The Hyperbaric oxygen (HBO2) at 1.5 atms (active) group (hyperbaric oxygen-chamber compressed to 1.5 atm abs and breathing 100% oxygen).” NCT01611194 ↗
1

“Hyperbaric oxygen (HBO2) at 1.5 ATA (active) group” NCT05173818 ↗

Modality Other / unclassified “dose of hyperbaric oxygen therapy (HBOT)” PMID 37009524 ↗ Dec 2022
Route Other “Patients also undergo HBOT once daily, 5 days a week, for 90 days (60 treatments total).” NCT00087815 ↗