drugset
Drugs / Efmarodocokin Alfa
last change Feb 2023 re-read 2 minutes ago

Efmarodocokin Alfa

also known as UTTR1147A · Il 22-fc · RG-7880 · RO-7021610

Protein / enzyme biologic

Developed for
ulcerative colitis · Crohn disease · acute graft versus host disease · chronic ulcer of skin · pneumonia
Investigated by
Genentech, Inc. · Biomedical Advanced Research and Development Authority

Trials 6 · a red edge is where a trial was stopped

today NCT04539470 · Ph 1 NCT04386616 · Ph 2 NCT03650413 · Ph 2 NCT03558152 · Ph 2 NCT02833389 · Ph 1 NCT02749630 · Ph 1
20162017201820192020202120222023202420252026
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT04539470 Nov 2020 → Feb 2023 acute graft versus host disease Genentech, Inc. Completed No outcome recorded
Phase 1 NCT02833389 Nov 2016 → Nov 2018 chronic ulcer of skin Genentech, Inc. Completed No outcome recorded
Phase 1 NCT02749630 Apr 2016 → Feb 2020 Crohn disease, ulcerative colitis Genentech, Inc. Completed No outcome recorded
Phase 23 trials
Phase 2 NCT04386616 Jun 2020 → Jan 2021 pneumonia Genentech, Inc. Completed No outcome recorded
Phase 2 NCT03650413 Jan 2019 → Jul 2022 Crohn disease, ulcerative colitis Genentech, Inc. Terminated No outcome recorded
Phase 2 NCT03558152 Oct 2018 → Dec 2021 ulcerative colitis Genentech, Inc. Completed No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as Efmarodocokin Alfa ClinicalTrials.gov intervention name — accepted as the source's own label NCT04539470 ↗
Known as Il 22-fc ChEMBL registry synonym — accepted as the source's own label CHEMBL4650250 ↗
Known as RG-7880 ChEMBL registry synonym — accepted as the source's own label CHEMBL4650250 ↗
Known as RO-7021610 ChEMBL registry synonym — accepted as the source's own label CHEMBL4650250 ↗
Known as UTTR1147A ClinicalTrials.gov intervention name — accepted as the source's own label NCT04386616 ↗
4

NCT03558152 ↗

NCT03650413 ↗

NCT02749630 ↗

NCT02833389 ↗
Action Activate “Efmarodocokin alfa (UTTR1147A) is a fusion protein agonist” PMID 36732049 ↗ Feb 2023
Modality Protein / enzyme biologic “Efmarodocokin alfa (UTTR1147A) is a fusion protein agonist” PMID 36732049 ↗ Feb 2023
Route Intravenous “repeat intravenous dosing of efmarodocokin alfa” PMID 36732049 ↗ Feb 2023