Drugs / Neladalkib
last change Jul 2025 re-read 2 minutes ago

Neladalkib

also known as NVL-655

Small molecule targets ALK via inhibition

Developed for
non-small cell lung carcinoma · metastatic neoplasm
Investigated by
Nuvalent Inc.

Trials 3 · a red edge is where a trial was stopped

20232024202520262027202820292030
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/21 trial
Phase 1/2 NCT05384626 Jun 2022 → Dec 2027 expected metastatic neoplasm Nuvalent Inc. Recruiting No outcome recorded
Phase 31 trial
Phase 3 NCT06765109 Jul 2025 → Dec 2029 expected non-small cell lung carcinoma Nuvalent Inc. Recruiting No outcome recorded
Phase not stated1 trial
NCT06834074 non-small cell lung carcinoma Nuvalent Inc. Available No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as Neladalkib ClinicalTrials.gov intervention name — accepted as the source's own label NCT06765109
1

NCT05384626

Known as NVL-655 “A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)” NCT05384626
2

“Neladalkib (NVL-655)” NCT06765109

NCT06834074

Action Inhibit “investigational ALK inhibitor” NCT06834074
Modality Small molecule CHEMBL6068023
Route Oral Oral Tablet of Neladalkib (NVL-655)” NCT05384626
Target ALK “investigational ALK inhibitor” NCT06834074