Drugs / Camlipixant
last change Jul 2026 re-read 2 minutes ago

Camlipixant

also known as BLU-5937 · AZ-13410937 · GSK5464714 · NEO-5937

Small molecule targets P2RX3 via inhibition

Developed for
respiratory system disorder · atopic eczema · irritable bowel syndrome
Investigated by
Bellus Health Inc. - a GSK company · GlaxoSmithKline

Trials 16 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 19 trials
Phase 1 NCT07684586 Jul 2026 → Aug 2027 expected GlaxoSmithKline Not yet recruiting No outcome recorded
Phase 1 NCT06497517 Jul → Aug 2024 Bellus Health Inc. - a GSK company Completed No outcome recorded
Phase 1 NCT06222892 Feb → Dec 2024 Bellus Health Inc. - a GSK company Completed No outcome recorded
Phase 1 NCT05959447 Jul → Oct 2023 Bellus Health Inc. - a GSK company Completed No outcome recorded
Phase 1 NCT05899829 Jun → Aug 2023 Bellus Health Inc. - a GSK company Completed No outcome recorded
Phase 1 NCT05570539 Oct 2022 → May 2024 Bellus Health Inc. - a GSK company Completed No outcome recorded
Phase 1 NCT06179537 Aug → Oct 2021 Bellus Health Inc. - a GSK company Completed No outcome recorded
Phase 1 NCT05244759 Aug → Sep 2020 Bellus Health Inc. - a GSK company Completed No outcome recorded
Phase 1 NCT03638180 Jul → Oct 2018 Bellus Health Inc. - a GSK company Completed No outcome recorded
Phase 24 trials
Phase 2 NCT07519395 Apr 2026 → Mar 2027 expected irritable bowel syndrome GlaxoSmithKline Recruiting No outcome recorded
Phase 2 NCT04693195 Dec 2020 → Oct 2021 atopic eczema Bellus Health Inc. - a GSK company Completed No outcome recorded
Phase 2 NCT04678206 Dec 2020 → Oct 2021 respiratory system disorder Bellus Health Inc. - a GSK company Completed No outcome recorded
Phase 2 NCT03979638 Jul 2019 → Apr 2020 Bellus Health Inc. - a GSK company Terminated No outcome recorded
Phase 33 trials
Phase 3 NCT07650084 Nov 2025 → Aug 2027 expected respiratory system disorder GlaxoSmithKline Recruiting No outcome recorded
Phase 3 NCT05600777 Dec 2022 → Jun 2026 overdue respiratory system disorder Bellus Health Inc. - a GSK company Active not recruiting No outcome recorded
Phase 3 NCT05599191 Oct 2022 → Dec 2025 respiratory system disorder Bellus Health Inc. - a GSK company Completed No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 18 sources stand behind the page.

FieldValueCited text
Known as camlipixant “SOOTHE (NCT04678206), a phase 2b, randomized, placebo-controlled trial, evaluated the efficacy and safety of P2X3 antagonist camlipixant in adults with refractory chronic cough” PMID 40043302 Jun 2025
6

NCT05959447

NCT07684586

NCT05899829

NCT06222892

NCT06497517

NCT07519395

Known as AZ-13410937 ChEMBL registry synonym — accepted as the source's own label CHEMBL5095035
Known as BLU-5937 “single dose of camlipixant (BLU-5937) 50 mg tablet” NCT05899829
10

NCT05244759

NCT05599191

NCT07650084

NCT04693195

NCT05600777

NCT05570539

NCT03638180

NCT03979638

NCT06179537

NCT04678206

Known as GSK5464714 “Camlipixant (GSK5464714)” NCT06497517
Known as NEO-5937 ChEMBL registry synonym — accepted as the source's own label CHEMBL5095035
Action Inhibit “selective P2X3 receptor antagonist” NCT03638180
1

“P2X purinoceptor 3 antagonist” CHEMBL5095035

Modality Small molecule CHEMBL5095035
Route Oral “BLU-5937 administered orally” NCT03638180
Target P2RX3 “P2X purinoceptor 3 antagonist” CHEMBL5095035