Drugs / OSI-7904
Trials 5
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 12 trials | ||||||
| Phase 1 | NCT00081237 | Feb 2004 → Aug 2005 | colorectal cancer | European Organisation for Research and Treatment of Cancer - EORTC | Completed | No outcome recorded |
| Phase 1 | NCT00116896 | Jun 2003 → Dec 2004 | cancer | OSI Pharmaceuticals | Completed | No outcome recorded |
| Phase 23 trials | ||||||
| Phase 2 | NCT00088270 | Aug 2004 → Aug 2005 | adenocarcinoma of gallbladder and extrahepatic biliary tract | OSI Pharmaceuticals | Completed | No outcome recorded |
| Phase 2 | NCT00116909 | Aug 2004 → Aug 2005 | head and neck cancer | OSI Pharmaceuticals | Completed | No outcome recorded |
| Phase 2 | NCT00073502 | Oct 2003 | gastric adenocarcinoma, gastroesophageal adenocarcinoma | OSI Pharmaceuticals | Completed | No outcome recorded |
Evidence & citations 10 cited values
Every value below carries the sentence it was read from. 7 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | OSI-7904 | ChEMBL registry synonym — accepted as the source's own label CHEMBL169896 ↗ |
| Known as | BW-1843 | ChEMBL registry synonym — accepted as the source's own label CHEMBL169896 ↗ |
| Known as | GS7904 | ChEMBL registry synonym — accepted as the source's own label CHEMBL169896 ↗ |
| Known as | Gw-1843 | ChEMBL registry synonym — accepted as the source's own label CHEMBL169896 ↗ |
| Known as | OSI-7904L | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00116896 ↗ |
| Known as | TCMDC-131928 | ChEMBL registry synonym — accepted as the source's own label CHEMBL169896 ↗ |
| Action | Inhibit | “PURPOSE: OSI-7904L is a liposomal formulation of a potent thymidylate synthase (TS) inhibitor.” PMID 17520255 ↗ May 20071“Thymidylate synthase inhibitor” CHEMBL169896 ↗ |
| Modality | Small molecule | — CHEMBL169896 ↗ |
| Route | Intravenous | “Patients receive oxaliplatin IV over 2 hours followed by OSI-7904L IV over 30 minutes on day 1.” NCT00081237 ↗ |
| Target | TYMS | “Thymidylate synthase inhibitor” CHEMBL169896 ↗ |