Drugs / DNK333
last change Jul 2011 re-read 2 minutes ago

DNK333

Small molecule targets TACR1 via inhibition

Developed for
irritable bowel syndrome · atopic eczema · chronic obstructive pulmonary disease
Investigated by
Novartis · Novartis Pharmaceuticals

Trials 4 · a red edge is where a trial was stopped

200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/21 trial
Phase 1/2 NCT01287325 Sep 2003 → Apr 2004 chronic obstructive pulmonary disease Novartis Completed No outcome recorded
Phase 23 trials
Phase 2 NCT01033097 Nov 2009 → Jul 2011 atopic eczema Novartis Pharmaceuticals Completed No outcome recorded
Phase 2 NCT00394173 Sep 2006 → Oct 2007 irritable bowel syndrome Novartis Completed No outcome recorded
Phase 2 NCT00699166 Apr 2004 → Sep 2005 irritable bowel syndrome Novartis Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as DNK333 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00394173
3

NCT00699166

NCT01287325

NCT01033097

Action Inhibit “DNK333, a novel neurokinin antagonist” PMID 21507028 Apr 2011
1

“Neurokinin 1 receptor antagonist” CHEMBL105060

Modality Small molecule CHEMBL105060
Route Oral “DNK333 25mg b.i.d. given orally for 4 weeks” NCT00394173
Target TACR1 “Neurokinin 1 receptor antagonist” CHEMBL105060