Drugs / MIK665
last change Jul 2024 re-read 2 minutes ago

MIK665

also known as S64315

targets MCL1 via inhibition

Developed for
acute myeloid leukemia · diffuse large B-cell lymphoma · myelodysplastic syndrome · non-Hodgkin lymphoma · plasma cell myeloma
Investigated by
ADIR, a Servier Group company · Servier · Novartis Pharmaceuticals

Trials 5 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT04702425 Jun 2021 → Jul 2024 acute myeloid leukemia, non-Hodgkin lymphoma, plasma cell myeloma Novartis Pharmaceuticals Terminated No outcome recorded
Phase 1 NCT03672695 Nov 2018 → Nov 2022 acute myeloid leukemia Servier Completed No outcome recorded
Phase 1 NCT02992483 Jul 2017 → Jun 2019 diffuse large B-cell lymphoma Novartis Pharmaceuticals Completed No outcome recorded
Phase 1 NCT02979366 Mar 2017 → May 2020 acute myeloid leukemia, myelodysplastic syndrome Servier Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT04629443 Feb 2021 → Aug 2023 acute myeloid leukemia Servier Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as MIK665 “S 64315 (also referred as MIK665) and azacitidine” NCT04629443
3

“S 64315 (also referred as MIK665) and venetoclax” NCT03672695

NCT02992483

NCT04702425

Known as S64315 S64315 should be administered 2 to 4 hours after venetoclax intake, via IV infusion.” NCT03672695
3

NCT03672695

NCT04629443

NCT02979366

Action Inhibit “a Mcl-1 Inhibitor” NCT02979366
Route Intravenous “via i.v. infusion” NCT02979366
Target MCL1 “MIK665, a Mcl-1 Inhibitor” NCT02992483