Drugs / (2R,6R)-hydroxynorketamine
(2R,6R)-hydroxynorketamine
also known as
(2r,6r)-hnk · (2r,6r)-hnk hydrochloride · (2r,6r)-hydroxynorketamine hydrochloride · HNK · HydroxyNorKetamine (HNK)
Trials 4 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT04711005 | Jan 2021 → Apr 2023 | major depressive disorder | National Institute of Mental Health (NIMH) | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT05864053 | Sep 2024 → Dec 2026 expected | neuropathy, painful | Rush University Medical Center | Recruiting | No outcome recorded |
| Phase 22 trials | ||||||
| Phase 2 | NCT07504601 | Jul 2026 → Dec 2030 expected | — | National Center for Complementary and Integrative Health (NCCIH) | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT06511908 | Nov 2024 → Jul 2027 expected | major depressive disorder | National Institute of Mental Health (NIMH) | Recruiting | No outcome recorded |
Evidence & citations 8 cited values
Every value below carries the sentence it was read from. 5 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | (2R,6R)-hydroxynorketamine | “This study will test whether a single dose of an experimental drug called (2R,6R)-hydroxynorketamine (HNK) can help reduce short term pain in healthy adults.” NCT07504601 ↗ |
| Known as | (2r,6r)-hnk | ChEMBL registry synonym — accepted as the source's own label CHEMBL4650718 ↗ |
| Known as | (2r,6r)-hnk hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL4650718 ↗ |
| Known as | (2r,6r)-hydroxynorketamine hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL4650718 ↗ |
| Known as | HNK | “Researchers want to know if a faster-acting drug, (2R,6R)-hydroxynorketamine (HNK), can better treat the symptoms of MDD.” NCT06511908 ↗ |
| Known as | HydroxyNorKetamine (HNK) | “This study will test whether a single dose of an experimental drug called (2R,6R)-hydroxynorketamine (HNK) can help reduce short term pain in healthy adults.” NCT07504601 ↗ |
| Modality | Small molecule | — CHEMBL4650718 ↗ |
| Route | Intravenous | “will be administered intravenously over a 40-minute period” NCT04711005 ↗ |