Drugs / Tarperprumig
last change Nov 2025 re-read 3 minutes ago

Tarperprumig

also known as ALXN1820

Monoclonal antibody

Developed for
anti-neutrophil cytoplasmic antibody-associated vasculitis · sickle cell disease
Investigated by
Alexion Pharmaceuticals, Inc. · Syneos Health

Trials 3

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT04631562 Jan 2021 → Sep 2022 — Alexion Pharmaceuticals, Inc. Completed No outcome recorded
Phase 22 trials
Phase 2 NCT07160608 Nov 2025 → Oct 2027 expected anti-neutrophil cytoplasmic antibody-associated vasculitis Alexion Pharmaceuticals, Inc. Recruiting No outcome recorded
Phase 2 NCT05565092 Feb 2023 → Jan 2024 sickle cell disease Alexion Pharmaceuticals, Inc. Terminated No outcome recorded Stop: Business

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as Tarperprumig “Tarperprumig (ALXN1820), a novel humanized bispecific antibody, binds properdin and albumin and is being developed to treat complement-mediated diseases.” PMID 40134111 ↗ Apr 2025
1

NCT07160608 ↗

Known as ALXN1820 “Tarperprumig (ALXN1820), a novel humanized bispecific antibody, binds properdin and albumin and is being developed to treat complement-mediated diseases.” PMID 40134111 ↗ Apr 2025
1

NCT05565092 ↗

Action Inhibit “Tarperprumig was well tolerated and completely inhibited the AP in healthy adults.” PMID 40134111 ↗ Apr 2025
Modality Monoclonal antibody — CHEMBL5315009 ↗
Route Subcutaneous “single doses of tarperprumig were administered via subcutaneous (SC) injection” PMID 40134111 ↗ Apr 2025