Drugs / Preladenant
last change Feb 2018 re-read 2 minutes ago

Preladenant

also known as MK-3814 · SCH 420814

Small molecule targets ADORA2A via inhibition

Developed for
Parkinson disease · drug-induced akathisia · drug-induced dyskinesia · neoplasm · parkinsonian disorder
Investigated by
Merck Sharp & Dohme LLC · Oregon Health and Science University

Trials 13 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT03099161 Jun → Nov 2017 neoplasm Merck Sharp & Dohme LLC Terminated No outcome recorded
Phase 1 NCT01465412 Nov 2011 → Jun 2012 liver disorder Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT01323855 Mar → Nov 2011 Parkinson disease Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT00845000 Apr 2009 → Apr 2010 Parkinson disease Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 25 trials
Phase 2 NCT01294800 Feb 2011 → Jun 2013 Parkinson disease Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 2 NCT00537017 Nov 2007 → Nov 2009 Parkinson disease, movement disorder, neurodegenerative disease Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 2 NCT00693472 Aug 2007 → Dec 2008 drug-induced akathisia, movement disorder Merck Sharp & Dohme LLC Terminated No outcome recorded
Phase 2 NCT00406029 Nov 2006 → Oct 2008 Parkinson disease, movement disorder, neurodegenerative disease Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 2 NCT00686699 Jul 2006 → Mar 2008 drug-induced akathisia, drug-induced dyskinesia, parkinsonian disorder Merck Sharp & Dohme LLC Terminated No outcome recorded
Phase 34 trials
Phase 3 NCT01227265 Nov 2010 → Apr 2013 Parkinson disease Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT01215227 Nov 2010 → Jul 2013 Parkinson disease Merck Sharp & Dohme LLC Terminated No outcome recorded
Phase 3 NCT01155466 Jul 2010 → Dec 2012 Parkinson disease Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT01155479 Jul 2010 → Jul 2013 Parkinson disease Merck Sharp & Dohme LLC Terminated No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 15 sources stand behind the page.

FieldValueCited text
Known as preladenant “Acute Effects of Preladenant (SCH 420814) on Dyskinesia and Parkinsonism in Levodopa Treated Participants (P05550)” NCT00845000
12

NCT01323855

NCT00693472

NCT00537017

NCT01155466

NCT01215227

NCT03099161

NCT01227265

NCT00406029

NCT01155479

NCT00686699

NCT01294800

NCT01465412

Known as MK-3814 ChEMBL registry synonym — accepted as the source's own label CHEMBL240624
Known as SCH 420814 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00845000
Action Inhibit “Preladenant is an adenosine 2A (A₂(A)) receptor antagonist.” PMID 21315654 Mar 2011
1

“Adenosine A2a receptor antagonist” CHEMBL240624

Modality Small molecule CHEMBL240624
Route Oral “Patients were assigned to receive 1, 2, 5, or 10 mg oral preladenant twice daily, or matching placebo for 12 weeks.” PMID 21315654 Mar 2011
Target ADORA2A “Adenosine A2a receptor antagonist” CHEMBL240624