Drugs / incomplete Freund's adjuvant

Trials 12 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 15 trials
Phase 1 NCT04009824 Jul 2019 → Mar 2020 vector-borne disease National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT03055000 Feb 2017 → Dec 2018 vector-borne disease National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT01585350 Oct 2012 → Jul 2014 melanoma Craig L Slingluff, Jr Completed No outcome recorded
Phase 1 NCT01842139 Dec 2011 → Feb 2015 acute myeloid leukemia with 11q23 abnormalities, acute myeloid leukemia with t(8;21)(q22;q22) translocation, acute myeloid leukemia, del(5q31-q32), acute myeloid leukemia, inv(16)(p13.1;q22) +2 University of Chicago Completed No outcome recorded
Phase 1 NCT00705640 May 2008 → Jun 2009 conjunctival cancer, cutaneous melanoma, ocular melanoma Craig L Slingluff, Jr Completed No outcome recorded
Phase 1/24 trials
Phase 1/2 NCT03617328 Nov 2018 → Jan 2024 melanoma Craig L Slingluff, Jr Completed No outcome recorded
Phase 1/2 NCT00683358 May 2008 → Apr 2009 malignant pancreatic neoplasm Tokyo University Unknown No outcome recorded
Phase 1/2 NCT00365937 Aug 2006 → Dec 2013 cutaneous melanoma Cliniques universitaires Saint-Luc- Université Catholique de Louvain Terminated No outcome recorded
Phase 1/2 NCT00145158 Jan 2005 → Nov 2007 melanoma Ludwig Institute for Cancer Research Terminated No outcome recorded
Phase 23 trials
Phase 2 NCT00273910 Jan 2006 → May 2010 melanoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00085189 May 2004 → Sep 2007 iris melanoma, medium/large size posterior uveal melanoma, mucosal melanoma, ocular melanoma with extraocular extension +1 University of Southern California Completed No outcome recorded
Phase 2 NCT00012246 Jul 2002 → Jul 2006 bile duct cancer, colorectal cancer, esophageal cancer, gallbladder cancer +3 The University of Texas Medical Branch, Galveston Terminated No outcome recorded
Also used as a comparator or background therapy in 107 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT01748747 Background Oct 2012 → Dec 2014 melanoma Mayo Clinic Completed No outcome recorded
Phase 0 NCT00640861 Background Aug 2008 → Apr 2015 female breast carcinoma Mayo Clinic Completed No outcome recorded
Phase 0 NCT00091286 Background Mar 2003 → Feb 2008 colorectal cancer Craig L Slingluff, Jr Terminated No outcome recorded
Phase 132 trials
Phase 1 NCT06789198 Background Jul 2025 → Nov 2028 expected fibrolamellar hepatocellular carcinoma University Hospital Tuebingen Recruiting No outcome recorded
Phase 1 NCT05937295 Background Sep 2023 → Sep 2026 expected fibrolamellar hepatocellular carcinoma University Hospital Tuebingen Recruiting No outcome recorded
Phase 1 NCT06218511 Background Nov 2022 → Aug 2025 overdue hepatocellular carcinoma National Cancer Institute, Naples Active not recruiting No outcome recorded
Phase 1 NCT04978727 Background Jul 2022 → Dec 2027 expected anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, diffuse intrinsic pontine glioma +3 Children's Oncology Group Active not recruiting No outcome recorded
Phase 1 NCT03879694 Background Jun 2019 → Feb 2025 atypical carcinoid tumor, lung carcinoid tumor, pancreatic neuroendocrine tumor Roswell Park Cancer Institute Completed No outcome recorded
Phase 1/217 trials
Phase 1/2 NCT05898763 Background Sep 2021 → Apr 2024 non-small cell lung carcinoma Erasmus Medical Center Completed No outcome recorded
Phase 1/2 NCT02938442 Background Jan 2019 → Jan 2023 triple-negative breast carcinoma University of Arkansas Completed No outcome recorded
Phase 1/2 NCT02264236 Background Oct 2015 → Jun 2021 lung neoplasm University of Arkansas Withdrawn No outcome recorded
Phase 1/2 NCT02425306 Background May 2015 → Aug 2017 melanoma Craig L Slingluff, Jr Terminated No outcome recorded
Phase 1/2 NCT02229084 Background Jan 2015 → Jan 2023 breast cancer University of Arkansas Completed No outcome recorded
Phase 250 trials
Phase 2 NCT05479045 Background Sep 2026 → Nov 2027 expected ovarian carcinoma, uterine adnexa cancer Georgetown University Not yet recruiting No outcome recorded
Phase 2 NCT06202066 Background Jul 2026 → Oct 2027 expected cancer, lung neuroendocrine neoplasm, pancreatic neuroendocrine neoplasm Roswell Park Cancer Institute Recruiting No outcome recorded
Phase 2 NCT07169617 Background Jul 2026 → Mar 2029 expected lung carcinoma National Cancer Institute (NCI) Not yet recruiting No outcome recorded
Phase 2 NCT03003195 Background Mar 2021 metastatic malignant neoplasm University of Arkansas Withdrawn No outcome recorded
Phase 2 NCT04013672 Background Mar 2020 → Aug 2021 glioblastoma David Peereboom Completed No outcome recorded
Phase 31 trial
Phase 3 NCT00019682 Background Dec 1999 → May 2011 cutaneous melanoma National Cancer Institute (NCI) Completed No outcome recorded
Phase not applicable3 trials
NCT05876195 Comparator Mar → Oct 2023 University of Oxford Unknown No outcome recorded
NCT00912574 Comparator Jun 2004 → Jul 2008 melanoma University of Virginia Completed No outcome recorded
NCT00006243 Background Oct 2000 → May 2006 melanoma National Cancer Institute (NCI) Completed No outcome recorded
Phase not stated1 trial
NCT05014607 Background cancer University Hospital Tuebingen Available No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 121 sources stand behind the page.

FieldValueCited text
Known as incomplete Freund's adjuvant ClinicalTrials.gov intervention name — accepted as the source's own label NCT00513578
50

NCT00022438

NCT00071981

NCT00030602

NCT00109811

NCT00104780

NCT02334865

NCT00077532

NCT00091338

NCT00001827

NCT00706992

NCT00062036

NCT00006385

NCT00079144

NCT00001703

NCT00705640

NCT00091104

NCT00381875

NCT00079157

NCT00031733

NCT00640861

NCT00091273

NCT00003222

NCT00003274

NCT00019487

NCT00005841

NCT00085189

NCT00357461

NCT00021164

NCT00006243

NCT01673217

NCT00072085

NCT00398138

NCT00118313

NCT00025181

NCT00118274

NCT06202066

NCT03879694

NCT00032045

NCT00020358

NCT00019721

NCT00089063

NCT00303836

NCT00295958

NCT00019383

NCT00003362

NCT00003339

NCT00019994

NCT00091143

NCT00003568

NCT00089193

Known as Montanide Montanide ISA-51 (Incomplete Freund's Adjuvant)” PMID 26500235 Oct 2015
Known as Montanide ISA 51 VG “Patients will be vaccinated 15 times over 12 months with a vaccine comprised of native and synthetic break-point cluster region-Abelson murine leukemia(BCR-ABL) specific...” NCT00428077
25

“NY-ESO-1 recombinant protein (250 µg) was mixed with Poly-ICLC (1 mg) and Montanide ISA-51 VG (1 mL) and administered SC directly following the ipilimumab infusion every 3...” NCT01810016

“Will receive an admixture of the wildtype and epitope enhanced TARP peptides emulsified with Montanide ISA 51 VG and granulocyte-macrophage colony-stimulating factor (GM-CSF).” NCT00972309

“Peptides will be administered subcutaneously (s.c.) together with the TLR1/2 ligand XS15 emulsified in Montanide ISA 51 VG as adjuvant” NCT05014607

“P10s-PADRE vaccine combined with MONTANIDE™ ISA 51 VG "Chemotherapy" Subcutaneous injection” NCT02264236

“the Toll-like receptor 1/2 ligand XS15 (50 μg) emulsified in Montanide ISA 51 VG (1:1).” NCT05937295

“NY-ESO-1 recombinant protein mixed with CpG 7909 and Montanide ISA-51 VG” NCT00299728

“P16_37-63 peptide combined with Montanide® ISA-51 VG” NCT02526316

“P10s-PADRE/MONTANIDE ISA 51 VG vaccine” NCT03003195

“mixed with 0.3 ml Montanide ISA-51 VG” NCT01462838

Montanide ISA 51 VG (1:1)” NCT06789198

NCT01842139

NCT01390064

NCT02229084

NCT01312389

NCT00821652

NCT00923195

NCT07169617

NCT00085189

NCT00019682

NCT01176461

NCT05876195

NCT01748747

NCT00089063

NCT02938442

NCT00004918

Known as Montanide ISA-51 “Arm 1, vaccine alone: patients received i.d. injections of Melan-A: 26-35 (A27L) and gp100: 209-217 (210M) peptides (250 µg each) formulated in Montanide ISA-51 plus s.c....” NCT00559026
43

“Participants were randomly assigned (1:1:1), using block randomisation and a computer-generated randomisation sequence, to treatment with either 200 nmol of AGS-v vaccine...” PMID 32534628 Jun 2020

“PD-L1 peptide (100 micrograms) emulsified with the adjuvant Montanide ISA-51 given subcutaneously 10 times every second week over the course of 26 weeks including a five-week break.” NCT03850522

“Montanide ISA™ 51 is a water-in-oil (W/O) emulsion composed of a mineral oil and a surfactant from the mannide monooleate family with immune stimulatory effect .” NCT06218511

“CDCA1,URLC10,KIF20A,DEPDC1 and MPHOSPH1 peptides (0.5, 1 or 2mg of each peptide) mixed with Montanide ISA 51 will be administered by subcutaneous injection.” NCT01259505

“PEP-CMV Component A mixed with Montanide ISA-51 (1:1 volume ratio) intradermally administered half in the RIGHT groin and half in the LEFT groin.” NCT03299309

“URLC10-117 peptide(1mg), VEGFR1 peptide(1mg) and VEGFR2 peptide(1mg) mixed with Montanide ISA 51 will be administered by subcutaneous injection.” NCT00681421

“Subcutaneous injection in the upper arm with 500mcg of FLU-v as 0.5ml emulsion in 0.25ml of WFI and 0.25ml of adjuvant Montanide ISA-51NCT03180801

“Patients receive carcinoembryonic antigen peptide 1-6D (CAP 1-6D) emulsified in Montanide ISA-51 adjuvant subcutaneously on day 1.” NCT00012246

“100 micrograms (mcg) granulocyte-macrophage colony-stimulating factor (GM-CSF) and 1 milliliter (mL) of Montanide ISA-51 adjuvant.” NCT05479045

“On each vaccination day, the URLC10 peptide (1mg) mixed with Montanide ISA 51 will be administered by endodermic injection” NCT00753844

“The vaccines also contain a substance called Montanide ISA51, which boosts the immune response to the vaccine.” NCT00295581

“vaccine comprising multiple synthetic melanoma peptides, sargramostim (GM-CSF), and Montanide ISA-51NCT00089206

“HLA-A\*2402 restricted epitope peptides URLC10, CDCA1, and KIF20A emulsified with Montanide ISA 51” NCT01950156

Montanide ISA-51, an incomplete Freund's adjuvant (IFA), is used in many vaccine trials” PMID 32350119 Apr 2020

“first, CpG 7909 oligodeoxynucleotides, and second, Montanide ISA-51.” NCT00112229

“SurVaxM will be mixed with Montanide ISA 51 before it is given.” NCT04978727

“UCPVax (combined with Montanide ISA51 as adjuvant)” NCT03946358

Montanide ISA-51 (Incomplete Freund's Adjuvant)” PMID 26500235 Oct 2015

“emulsified in 2 ml of Montanide ISA-51NCT00005629

NCT03939234

NCT02455557

NCT00080353

NCT04013672

NCT03617328

NCT00059475

NCT00019396

NCT00678509

NCT00365937

NCT00091286

NCT00912574

NCT01585350

NCT02425306

NCT00020475

NCT02429440

NCT05898763

NCT02452307

NCT04009824

NCT00020267

NCT00001832

NCT00145158

NCT00199836

NCT00273910

NCT00184067

Known as Montanide(R) ISA-51 “a synthetic CpG 7909 ODN (deoxycytidyl-deoxyguanosin oligodeoxy-nucleotides) mixed with NY-ESO-1 peptide p157-165 and incomplete Freund's adjuvants (Montanide(R) ISA-51) led to...” PMID 19728336 Feb 2010
Known as VEGFR1-A24-1084 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00683358
Modality Other / unclassified “incomplete Freund's adjuvant” NCT00003339
Route Subcutaneous “injected subcutaneously every four weeks” NCT00001703