Drugs / Metaxalone
last change Jun 2025 re-read 2 minutes ago

Metaxalone

also known as AHR-438 · Flexura · M640 · Metaxalona · NSC-170959 · Skelaxin · Zorane

Small molecule

Developed for
osteoarthritis, knee · lumbar spinal stenosis · sciatica
Investigated by
Rothman Institute Orthopaedics

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) SKELAXIN 1962-08-13 fda.gov

Trials 1 · a red edge is where a trial was stopped

today
US approved 1962
NCT04003350 · not/applicable
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
NCT04003350 Dec 2017 → Nov 2018 osteoarthritis, knee Rothman Institute Orthopaedics Completed No outcome recorded
Also used as a comparator or background therapy in 6 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 46 trials
Phase 4 NCT06484192 Comparator Jun 2024 → Jun 2025 Rothman Institute Orthopaedics Unknown No outcome recorded
Phase 4 NCT06348303 Comparator May → Sep 2024 Primus Pharmaceuticals Completed No outcome recorded
Phase 4 NCT06382662 Comparator Apr → Dec 2024 cognitive disorder Primus Pharmaceuticals Completed No outcome recorded
Phase 4 NCT06157177 Comparator Nov 2023 → Nov 2026 expected lumbar spinal stenosis, sciatica Primus Pharmaceuticals Recruiting No outcome recorded
Phase 4 NCT04990804 Background Aug 2021 → Feb 2022 spinal cord disorder, substance-related disorder Vanderbilt University Medical Center Terminated No outcome recorded

Evidence & citations 10 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as Metaxalone “Alternative muscle relaxers (Metaxalone 800 mg TID or Tizanidine 2-6 mg TID)” NCT04990804
6

NCT06157177

NCT06382662

NCT06348303

NCT06484192

NCT04003350

NCT03068897

Known as AHR-438 ChEMBL registry synonym — accepted as the source's own label CHEMBL1079604
Known as Flexura ChEMBL registry synonym — accepted as the source's own label CHEMBL1079604
Known as M640 “Metaxalone 640 mg (M640)” NCT06382662
Known as Metaxalona ChEMBL registry synonym — accepted as the source's own label CHEMBL1079604
Known as NSC-170959 ChEMBL registry synonym — accepted as the source's own label CHEMBL1079604
Known as Skelaxin ChEMBL registry synonym — accepted as the source's own label CHEMBL1079604
Known as Zorane ChEMBL registry synonym — accepted as the source's own label CHEMBL1079604
Modality Small molecule CHEMBL1079604
Route Oral “Metaxalone 800mg PO TID” NCT04003350