Drugs / ERGOLOID
last change Jan 2023 re-read 9 days ago

ERGOLOID

targets HTR1A, HTR1B via activation

Developed for
fragile X syndrome · vascular dementia
Investigated by
Elizabeth Berry-Kravis · FRAXA Research Foundation · Purposeful IKE

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) HYDERGINE — 1975-06-02 fda.gov ↗
Approved US (FDA) HYDERGINE — 1953-11-05 fda.gov ↗

Trials 1

today
US approved 1953
NCT05030129 · Ph 2
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 21 trial
Phase 2 NCT05030129 Oct 2021 → Jan 2023 fragile X syndrome Elizabeth Berry-Kravis Completed No outcome recorded
Comparator or background therapy1 trial
Phase 2 NCT01475578 Comparator Mar → Oct 2002 vascular dementia Sinphar Pharmaceutical Co., Ltd Completed No outcome recorded

Evidence & citations 20 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as ERGOLOID ChEMBL registry synonym — accepted as the source's own label CHEMBL2364968 ↗
Known as Alkergot ChEMBL registry synonym — accepted as the source's own label CHEMBL2364968 ↗
Known as Circanol ChEMBL registry synonym — accepted as the source's own label CHEMBL2364968 ↗
Known as Co-dergocrine mesilate ChEMBL registry synonym — accepted as the source's own label CHEMBL2364968 ↗
Known as Deapril ChEMBL registry synonym — accepted as the source's own label CHEMBL2364968 ↗
Known as Deapril-st ChEMBL registry synonym — accepted as the source's own label CHEMBL2364968 ↗
Known as Dihydroergotoxine mesilate ChEMBL registry synonym — accepted as the source's own label CHEMBL2364968 ↗
Known as Dihydroergotoxine mesylate ChEMBL registry synonym — accepted as the source's own label CHEMBL2364968 ↗
Known as Dihydroergotoxine methanesulfonate ChEMBL registry synonym — accepted as the source's own label CHEMBL2364968 ↗
Known as Dihydrogenated ergot alkaloids ChEMBL registry synonym — accepted as the source's own label CHEMBL2364968 ↗
Known as Ergoloid mesilates ChEMBL registry synonym — accepted as the source's own label CHEMBL2364968 ↗
Known as Ergoloid Mesylates ClinicalTrials.gov intervention name — accepted as the source's own label NCT05030129 ↗
1

NCT01475578 ↗

Known as Gerimal ChEMBL registry synonym — accepted as the source's own label CHEMBL2364968 ↗
Known as Hydergine ChEMBL registry synonym — accepted as the source's own label CHEMBL2364968 ↗
Known as Hydergine lc ChEMBL registry synonym — accepted as the source's own label CHEMBL2364968 ↗
Known as Hydrogenated ergot alkaloids ChEMBL registry synonym — accepted as the source's own label CHEMBL2364968 ↗
Action Activate “Serotonin 1a (5-HT1a) receptor agonist” CHEMBL2364968 ↗
1

“Serotonin 1b (5-HT1b) receptor agonist” CHEMBL2364968 ↗

Route Oral “Ergoloid Mesylates tablet (manufactured by Tianjin Huajin Pharmaceutical Factory; Batch number: 011230), 2 tablets/time, 3 times/day, orally before meal” NCT01475578 ↗
Target HTR1A “Serotonin 1a (5-HT1a) receptor agonist” CHEMBL2364968 ↗
Target HTR1B “Serotonin 1b (5-HT1b) receptor agonist” CHEMBL2364968 ↗